BDBM387273 US10292981, Example 135

SMILES CNc1ccc(cc1-c1ccc(NC(=O)c2c(F)cccc2F)cc1)C1=NOC(C)(C)C1=O

InChI Key InChIKey=LDGXRCFIEHUTCC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 387273   

TargetInterleukin-2(Homo sapiens (Human))
Lupin

US Patent
LigandPNGBDBM387273(US10292981, Example 135)
Affinity DataIC50: <100nMAssay Description:Jurkat T cells were seeded at a density of 0.5 to 1 million cells per well in RPMI medium. Test compounds from this invention were added to the cells...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear factor of activated T-cells, cytoplasmic 2(Homo sapiens (Human))
Lupin

US Patent
LigandPNGBDBM387273(US10292981, Example 135)
Affinity DataIC50: <500nMAssay Description:HEK 293 cells were stably transfected with a NFAT-Luc reporter gene. 30,000-80,000 cells were seeded per well. Test compounds from this invention wer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStore-operated calcium entry-associated regulatory factor(Homo sapiens (Human))
Lupin

US Patent
LigandPNGBDBM387273(US10292981, Example 135)
Affinity DataIC50: <1.00E+3nMAssay Description:Jurkat E6.1 cells were seeded at a density of 1-2×105 cells per well in calcium-4 dye prepared in calcium free HBSS (Sigma, USA). Test compounds from...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent