BDBM422652 5-Ethyl-4-methyl-N-[4-[(2S)-morpholin-2-yl]phenyl]-1H-pyrazole-3-carboxamide::US10508107, Example 1::US11312711, Example 1

SMILES CCc1[nH]nc(C(=O)Nc2ccc(cc2)[C@H]2CNCCO2)c1C

InChI Key

Data  2 KI  2 IC50  2 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 422652   

TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM422652(5-Ethyl-4-methyl-N-[4-[(2S)-morpholin-2-yl]phenyl]...)
Affinity DataKi:  2.75E+4nMAssay Description:Binding to dopamine transporter (DAT) in vitro. Human embryonic kidney (HEK) 293 cells (Invitrogen, Zug, Switzerland) stably transfected with human D...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM422652(5-Ethyl-4-methyl-N-[4-[(2S)-morpholin-2-yl]phenyl]...)
Affinity DataKi:  2.75E+4nMAssay Description:Binding to dopamine transporter (DAT) in vitro. Human embryonic kidney (HEK) 293 cells (Invitrogen, Zug, Switzerland) stably transfected with human D...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM422652(5-Ethyl-4-methyl-N-[4-[(2S)-morpholin-2-yl]phenyl]...)
Affinity DataIC50:  2.17E+5nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of the test items on hERG (human-ether-a-go-go related gene) potassium chann...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTrace amine-associated receptor 1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM422652(5-Ethyl-4-methyl-N-[4-[(2S)-morpholin-2-yl]phenyl]...)
Affinity DataEC50:  58.5nMAssay Description:For the construction of expression plasmids the coding sequences of human TAAR1 were amplified from genomic DNA essentially as described by Lindemann...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM422652(5-Ethyl-4-methyl-N-[4-[(2S)-morpholin-2-yl]phenyl]...)
Affinity DataIC50:  2.17E+5nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of the test items on hERG (human-ether-a-go-go related gene) potassium chann...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTrace amine-associated receptor 1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM422652(5-Ethyl-4-methyl-N-[4-[(2S)-morpholin-2-yl]phenyl]...)
Affinity DataEC50:  58.5nMAssay Description:For the construction of expression plasmids the coding sequences of human TAAR 1 were amplified from genomic DNA essentially as described by Lindeman...More data for this Ligand-Target Pair