BDBM50042357 CHEMBL334271::N-(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-N-(3,4,5-trichloro-phenyl)-formamide

SMILES Cc1c(CN(C=O)c2cc(Cl)c(Cl)c(Cl)c2)cnc2nc(N)nc(N)c12

InChI Key InChIKey=CIURVVJJFVTBEE-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50042357   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042357(CHEMBL334271 | N-(2,4-Diamino-5-methyl-pyrido[2,3-...)
Affinity DataIC50:  94nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042357(CHEMBL334271 | N-(2,4-Diamino-5-methyl-pyrido[2,3-...)
Affinity DataIC50:  1.82E+4nMAssay Description:Inhibitory concentration required to decrease cell viability in cell growth culture against breast carcinoma cells MCF-7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042357(CHEMBL334271 | N-(2,4-Diamino-5-methyl-pyrido[2,3-...)
Affinity DataIC50:  520nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042357(CHEMBL334271 | N-(2,4-Diamino-5-methyl-pyrido[2,3-...)
Affinity DataIC50:  250nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042357(CHEMBL334271 | N-(2,4-Diamino-5-methyl-pyrido[2,3-...)
Affinity DataIC50:  94nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042357(CHEMBL334271 | N-(2,4-Diamino-5-methyl-pyrido[2,3-...)
Affinity DataIC50:  520nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042357(CHEMBL334271 | N-(2,4-Diamino-5-methyl-pyrido[2,3-...)
Affinity DataIC50:  250nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed