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Found 5 Enz. Inhib. hit(s) with Target = 'Dihydrofolate reductase' and Ligand = 'BDBM50042357'
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042357(CHEMBL334271 | N-(2,4-Diamino-5-methyl-pyrido[2,3-...)
Affinity DataIC50:  250nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042357(CHEMBL334271 | N-(2,4-Diamino-5-methyl-pyrido[2,3-...)
Affinity DataIC50:  250nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042357(CHEMBL334271 | N-(2,4-Diamino-5-methyl-pyrido[2,3-...)
Affinity DataIC50:  520nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042357(CHEMBL334271 | N-(2,4-Diamino-5-methyl-pyrido[2,3-...)
Affinity DataIC50:  520nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50042357(CHEMBL334271 | N-(2,4-Diamino-5-methyl-pyrido[2,3-...)
Affinity DataIC50:  1.82E+4nMAssay Description:Inhibitory concentration required to decrease cell viability in cell growth culture against breast carcinoma cells MCF-7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed