BDBM50049730 2-(5-(2-methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid::CHEMBL56337::Epalrestat::{5-[(E)-2-Methyl-3-phenyl-prop-2-en-(Z)-ylidene]-4-oxo-2-thioxo-thiazolidin-3-yl}-acetic acid
SMILES C\C(\C=C1/SC(=S)N(CC(O)=O)C1=O)=C/c1ccccc1
InChI Key InChIKey=CHNUOJQWGUIOLD-NFZZJPOKSA-N
Data 61 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50049730
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Quaid-I-Azam University
Curated by ChEMBL
Quaid-I-Azam University
Curated by ChEMBL
Affinity DataIC50: 620nMAssay Description:Inhibition of human recombinant ALR2 expressed in Escherichia coli using DL-glyceraldehyde as substrate and NADPH preincubated for 5 mins followed by...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Quaid-I-Azam University
Curated by ChEMBL
Quaid-I-Azam University
Curated by ChEMBL
Affinity DataIC50: 510nMAssay Description:Inhibition of ALR2 in rat erythrocytes assessed as reduction in sorbitol accumulation incubated for 3 hrs in presence of 28 mM glucose by gas chromat...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Quaid-I-Azam University
Curated by ChEMBL
Quaid-I-Azam University
Curated by ChEMBL
Affinity DataIC50: 860nMAssay Description:Inhibition of ALR2 in rat sciatic nerve assessed as reduction in sorbitol accumulation incubated for 3 hrs in presence of 28 mM glucose by gas chroma...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Quaid-I-Azam University
Curated by ChEMBL
Quaid-I-Azam University
Curated by ChEMBL
Affinity DataIC50: 530nMAssay Description:Inhibition of ALR2 in rat lens assessed as reduction in sorbitol accumulation incubated for 3 hrs in presence of 28 mM glucose by gas chromatographic...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Quaid-I-Azam University
Curated by ChEMBL
Quaid-I-Azam University
Curated by ChEMBL
Affinity DataIC50: 3.21E+3nMAssay Description:Inhibition of rat kidney ALR1 using DL-glyceraldehyde as substrate and NADPH preincubated for 5 mins followed by substrate addition and measured for ...More data for this Ligand-Target Pair