BDBM50078618 CHEMBL3415173::US9278093, 2
SMILES Cc1nnc2CCc3cc(cc(F)c3-n12)-c1cncc(F)c1C
InChI Key InChIKey=MQHYBBKWHVWRSQ-UHFFFAOYSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50078618
Affinity DataIC50: 6nMT: 2°CAssay Description:Compounds of the Examples 1 to 3 were assayed for V79-Human-CYP11B2 and V79-Human-CYP11B1 by modifying the protocol described in J. Steroid Biochem. ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.42E+3nMT: 2°CAssay Description:Compounds of the Examples 1 to 3 were assayed for V79-Human-CYP11B2 and V79-Human-CYP11B1 by modifying the protocol described in J. Steroid Biochem. ...More data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
Saarland University And Helmholtz Institute For Pharmaceutical Research Saarland (Hips)
Curated by ChEMBL
Saarland University And Helmholtz Institute For Pharmaceutical Research Saarland (Hips)
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CYP17 expressed in Escherichia coli coexpressing human CYP17 and NADPH-P450 reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of human CYP11B2 expressed in V79 MZh cells using [14C]-deoxycorticosterone substrate incubated for 6 hrs by HPTLC methodMore data for this Ligand-Target Pair
TargetAromatase(Homo sapiens (Human))
Saarland University And Helmholtz Institute For Pharmaceutical Research Saarland (Hips)
Curated by ChEMBL
Saarland University And Helmholtz Institute For Pharmaceutical Research Saarland (Hips)
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP19 in human placental microsomes using [1beta-3H]androstenedione substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 4.52E+3nMAssay Description:Inhibition of human CYP11B1 expressed in V79 MZh cells using [14C]-deoxycorticosterone substrate incubated for 6 hrs by HPTLC methodMore data for this Ligand-Target Pair