BDBM50148478 CHEMBL3769965::US10702504, Compound A

SMILES COc1ccc(Oc2cc3n(C)c(=O)n(C)c3cc2NS(=O)(=O)c2ccc(OC)c(OC)c2)cc1

InChI Key InChIKey=KNVIUMWNYXDULF-UHFFFAOYSA-N

Data  5 IC50  3 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50148478   

TargetTranscription intermediary factor 1-alpha(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50148478(CHEMBL3769965 | US10702504, Compound A)
Affinity DataIC50:  430nMAssay Description:Inhibition of N-terminal His6-SUMO-1-tagged recombinant human TRIM24 bromodomain expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by Alpha Scr...More data for this Ligand-Target Pair
TargetPeregrin(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50148478(CHEMBL3769965 | US10702504, Compound A)
Affinity DataIC50:  340nMAssay Description:Inhibition of BRPF1B (unknown origin) by Alpha Screen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50148478(CHEMBL3769965 | US10702504, Compound A)
Affinity DataIC50:  1.75E+3nMAssay Description:Inhibition of BRPF2 BRD1 (unknown origin) by Alpha Screen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription intermediary factor 1-alpha(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50148478(CHEMBL3769965 | US10702504, Compound A)
Affinity DataIC50:  750nMAssay Description:The alpha assay was used to assess the binding of the compounds of the application to TRIM24 at various concentrations. All compounds were added at c...More data for this Ligand-Target Pair
TargetPeregrin(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50148478(CHEMBL3769965 | US10702504, Compound A)
Affinity DataKd:  137nMAssay Description:Binding affinity to BRPF1B (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50148478(CHEMBL3769965 | US10702504, Compound A)
Affinity DataKd:  1.13E+3nMAssay Description:Binding affinity to BRPF2 BRD1 (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain and PHD finger-containing protein 3(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50148478(CHEMBL3769965 | US10702504, Compound A)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of BRPF3 (unknown origin) by Alpha Screen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription intermediary factor 1-alpha(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50148478(CHEMBL3769965 | US10702504, Compound A)
Affinity DataKd:  222nMAssay Description:Binding affinity to N-terminal His6-SUMO-1-tagged recombinant human TRIM24 bromodomain expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by iso...More data for this Ligand-Target Pair