BDBM50148478 CHEMBL3769965::US10702504, Compound A
SMILES COc1ccc(Oc2cc3n(C)c(=O)n(C)c3cc2NS(=O)(=O)c2ccc(OC)c(OC)c2)cc1
InChI Key InChIKey=KNVIUMWNYXDULF-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50148478
TargetTranscription intermediary factor 1-alpha(Homo sapiens (Human))
University Of Oxford
Curated by ChEMBL
University Of Oxford
Curated by ChEMBL
Affinity DataIC50: 430nMAssay Description:Inhibition of N-terminal His6-SUMO-1-tagged recombinant human TRIM24 bromodomain expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by Alpha Scr...More data for this Ligand-Target Pair
Affinity DataIC50: 340nMAssay Description:Inhibition of BRPF1B (unknown origin) by Alpha Screen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.75E+3nMAssay Description:Inhibition of BRPF2 BRD1 (unknown origin) by Alpha Screen assayMore data for this Ligand-Target Pair
TargetTranscription intermediary factor 1-alpha(Homo sapiens (Human))
University Of Oxford
Curated by ChEMBL
University Of Oxford
Curated by ChEMBL
Affinity DataIC50: 750nMAssay Description:The alpha assay was used to assess the binding of the compounds of the application to TRIM24 at various concentrations. All compounds were added at c...More data for this Ligand-Target Pair
Affinity DataKd: 137nMAssay Description:Binding affinity to BRPF1B (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair
Affinity DataKd: 1.13E+3nMAssay Description:Binding affinity to BRPF2 BRD1 (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetBromodomain and PHD finger-containing protein 3(Homo sapiens (Human))
University Of Oxford
Curated by ChEMBL
University Of Oxford
Curated by ChEMBL
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of BRPF3 (unknown origin) by Alpha Screen assayMore data for this Ligand-Target Pair
TargetTranscription intermediary factor 1-alpha(Homo sapiens (Human))
University Of Oxford
Curated by ChEMBL
University Of Oxford
Curated by ChEMBL
Affinity DataKd: 222nMAssay Description:Binding affinity to N-terminal His6-SUMO-1-tagged recombinant human TRIM24 bromodomain expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by iso...More data for this Ligand-Target Pair