BDBM50177643 (R)-[8-chloro-6-(1-piperazinyl)-1H-benzo[5,6]]cyclohepta[1,2-b]pyridine-11-yl]-1-(methylsulfonyl)piperidine::CHEMBL383114

SMILES CS(=O)(=O)N1CCC(CC1)[C@@H]1c2ccc(Cl)cc2C(=Cc2cccnc12)N1CCNCC1

InChI Key InChIKey=ZMGCFGGMTCMSDP-HSZRJFAPSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50177643   

TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50177643((R)-[8-chloro-6-(1-piperazinyl)-1H-benzo[5,6]]cycl...)
Affinity DataIC50:  72nMAssay Description:Inhibition of farnesyltransferase activity in COS7 cells transfected with Ras gene in soft agar proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50177643((R)-[8-chloro-6-(1-piperazinyl)-1H-benzo[5,6]]cycl...)
Affinity DataIC50:  7nMAssay Description:Inhibition of farnesyltransferase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed