BDBM50204291 CHEMBL3953104::US20230295171, Example 76

SMILES Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)c(C#N)c3CNC(=O)c23)c1

InChI Key InChIKey=UOBUBZWFFCOCAE-DLBZAZTESA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50204291   

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50204291(CHEMBL3953104 | US20230295171, Example 76)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human C-terminal 6His-tagged SYK (356 to 635 residues) expressed in Sf9 insect cells using 5-carboxyfluorescein(FAM)-EEPLYWSFPAKKK-NH2 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50204291(CHEMBL3953104 | US20230295171, Example 76)
Affinity DataIC50:  0.501nMAssay Description:YK protein is prepared from cDNA encoding human spleen tyrosine kinase and is expressed in insect cells using a baculovirus expression vector. The cD...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50204291(CHEMBL3953104 | US20230295171, Example 76)
Affinity DataEC50: <3nMAssay Description:Inhibition of SYK in TgM-stimulated human Ramos cells expressing RA1/GFP-tagged BLNK assessed as reduction in RA1/GFP-tagged BLNK phosphorylation pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed