BDBM50204697 4'-{6-[(trans-4-hydroxy-cyclohexylamino)-methyl]-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl}-biphenyl-4-ol::CHEMBL242535

SMILES O[C@H]1CC[C@@H](CC1)NCc1ccc-2c(Cc3c(n[nH]c-23)-c2ccc(cc2)-c2ccc(O)cc2)c1

InChI Key InChIKey=OWEWWKZBRPUVAP-ALOJWSFFSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50204697   

TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50204697(4'-{6-[(trans-4-hydroxy-cyclohexylamino)-methyl]-1...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of recombinant CHK1 assessed as human Cdc25C phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50204697(4'-{6-[(trans-4-hydroxy-cyclohexylamino)-methyl]-1...)
Affinity DataEC50:  2.30E+3nMAssay Description:Antiproliferative activity against human SW620 cells by soft agar assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50204697(4'-{6-[(trans-4-hydroxy-cyclohexylamino)-methyl]-1...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of G2/M cell population in human H1299 cells by FACS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed