BDBM50238541 CHEMBL4092336
SMILES COC(=O)c1ccccc1NC(=O)CSc1nc2cc(OC)ccc2[nH]1
InChI Key InChIKey=GZBULYAKSCNNPA-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 16 hits for monomerid = 50238541
TargetProtein arginine N-methyltransferase 7(Homo sapiens (Human))
Shandong University
Curated by ChEMBL
Shandong University
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human N-terminal His-tagged full length PRMT7 expressed in baculovirus using of histone H4 as substrate preincubated for 15...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute Of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 0.330nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-arginine methyltransferase CARM1(Homo sapiens (Human))
Shandong University
Curated by ChEMBL
Shandong University
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human kidney reninMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 6(Homo sapiens (Human))
Shandong University
Curated by ChEMBL
Shandong University
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human N-terminal His-tagged PRMT6 (2 to 375 residues) expressed in Escherichia coli using of histone H3 as substrate preinc...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 8(Homo sapiens (Human))
Shandong University
Curated by ChEMBL
Shandong University
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT8 (61 to 394 residues) expressed in baculovirus infected Sf9 cell expression system using ...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Homo sapiens (Human))
Shandong University
Curated by ChEMBL
Shandong University
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of NSD1 (unknown origin) preincubated for 15 mins followed by [3H]-SAM addition measured after 4 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Shandong University
Curated by ChEMBL
Shandong University
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of 5-HT uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase SETD7(Homo sapiens (Human))
Shandong University
Curated by ChEMBL
Shandong University
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of SET7/9 (unknown origin) after 60 mins by Alpha LISA assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of BRD4 (unknown origin) using SGRG-K(Ac)-GG-K(Ac)-GLG-K-(Ac)-GGA-K(Ac)-RHRKVGG-K(Biotin) peptide as substrate preincubated for 10 mins fo...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of GCN5 (unknown origin) using H3 as substrate and Ac-CoA as cofactor preincubated for 10 mins followed by substrate/cofactor addition mea...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University
Curated by ChEMBL
Shandong University
Curated by ChEMBL
Affinity DataKd: 987nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Shandong University
Curated by ChEMBL
Shandong University
Curated by ChEMBL
Affinity DataIC50: 330nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues) /human N-terminal His-tagged MEP50 (2 to end residues) expressed in ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human N-terminal GST-tagged PRMT3 (2 to end residues) expressed in Escherichia coli using histone H4 as substrate preincubated for 15 m...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged PRMT1 (2 to end residues) expressed in baculovirus infected Sf9 cell expression system using hi...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Csir-Indian Institute Of Chemical Biology
Curated by ChEMBL
Csir-Indian Institute Of Chemical Biology
Curated by ChEMBL
Affinity DataIC50: 330nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
Shandong University
Curated by ChEMBL
Shandong University
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of DOT1L (unknown origin) using biotinylated H3K79me2 as substrate preincubated for 15 mins followed by substrate/ SAM addition measured a...More data for this Ligand-Target Pair