BDBM50258768 CHEMBL4078901

SMILES Fc1ccc(cc1)-c1cccc(NC(=O)Nc2ccc(Cl)cc2)c1

InChI Key InChIKey=XVGAWVMMVIOVSW-UHFFFAOYSA-N

Data  9 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50258768   

TargetCannabinoid receptor 2(MOUSE)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50258768(CHEMBL4078901)
Affinity DataIC50:  151nMAssay Description:Allosteric modulation of CB1 receptor in CD-1 mouse cerebellar membranes assessed as inhibition of CP55,940-induced [35S]GTPgammaS binding after 60 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50258768(CHEMBL4078901)
Affinity DataIC50:  23nMAssay Description:Allosteric modulation of human CB1 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobiliza...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50258768(CHEMBL4078901)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at human CB2 receptor expressed in CHO cells co-expressing Galpha16 assessed as inhibition of CP55,940-induced calcium mobilizati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(MOUSE)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50258768(CHEMBL4078901)
Affinity DataEC50:  790nMAssay Description:PAM antagonist activity at CB1 receptor in CD-1 mouse cerebellar membranes assessed as increase in [3H]CP55,940 binding after 90 mins relative to con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50258768(CHEMBL4078901)
Affinity DataIC50:  151nMAssay Description:Allosteric antagonist activity at mouse CB1 receptor by GTPgammaS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50258768(CHEMBL4078901)
Affinity DataIC50:  151nMAssay Description:Allosteric modulation of CB1 receptor (unknown origin) assessed as inhibition of CP55940-induced [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50258768(CHEMBL4078901)
Affinity DataIC50:  23nMAssay Description:Allosteric antagonist activity at human CB1 receptor by Ca2+ assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50258768(CHEMBL4078901)
Affinity DataIC50:  23nMAssay Description:Allosteric antagonist activity at human CB1 receptor by Ca2+ assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50258768(CHEMBL4078901)
Affinity DataIC50:  151nMAssay Description:Allosteric antagonist activity at mouse CB1 receptor by GTPgammaS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50258768(CHEMBL4078901)
Affinity DataIC50:  23nMAssay Description:Allosteric modulation of CB1 receptor (unknown origin) assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed