BDBM50266416 CHEMBL458224::N-[2-(3,5-Dimethylpyrazol-1-yl)-6-(2-(R)-methoxymethylpyrrolidin-1-yl)pyrimidin-4-yl]acetamide

SMILES COC[C@H]1CCCN1c1cc(NC(C)=O)nc(n1)-n1nc(C)cc1C

InChI Key InChIKey=FGADYIBOWLXZLA-CQSZACIVSA-N

Data  6 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50266416   

TargetAdenosine receptor A2a(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266416(CHEMBL458224 | N-[2-(3,5-Dimethylpyrazol-1-yl)-6-(...)
Affinity DataKi:  4.70nMAssay Description:Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266416(CHEMBL458224 | N-[2-(3,5-Dimethylpyrazol-1-yl)-6-(...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]-ZM241385 from human adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266416(CHEMBL458224 | N-[2-(3,5-Dimethylpyrazol-1-yl)-6-(...)
Affinity DataKi:  19nMAssay Description:Inhibition of human adenosine A3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266416(CHEMBL458224 | N-[2-(3,5-Dimethylpyrazol-1-yl)-6-(...)
Affinity DataKi:  48nMAssay Description:Displacement of [3H]ZM241385 from rat adenosine A2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266416(CHEMBL458224 | N-[2-(3,5-Dimethylpyrazol-1-yl)-6-(...)
Affinity DataKi:  145nMAssay Description:Inhibition of human adenosine A2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266416(CHEMBL458224 | N-[2-(3,5-Dimethylpyrazol-1-yl)-6-(...)
Affinity DataKi:  162nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266416(CHEMBL458224 | N-[2-(3,5-Dimethylpyrazol-1-yl)-6-(...)
Affinity DataIC50:  85nMAssay Description:Antagonist activity at human adenosine A2A receptor assessed as inhibition of CGS-21680-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266416(CHEMBL458224 | N-[2-(3,5-Dimethylpyrazol-1-yl)-6-(...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266416(CHEMBL458224 | N-[2-(3,5-Dimethylpyrazol-1-yl)-6-(...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266416(CHEMBL458224 | N-[2-(3,5-Dimethylpyrazol-1-yl)-6-(...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266416(CHEMBL458224 | N-[2-(3,5-Dimethylpyrazol-1-yl)-6-(...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50266416(CHEMBL458224 | N-[2-(3,5-Dimethylpyrazol-1-yl)-6-(...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed