BDBM50277584 CHEMBL482968::N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-styrylpyrimidin-4-amine
SMILES CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(C=Cc2ccccc2)n1
InChI Key InChIKey=BLQYVHBZHAISJM-UHFFFAOYSA-N
Data 33 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50277584
Affinity DataIC50: 14nMAssay Description:Inhibition of aurora A kinaseChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 295nMAssay Description:Inhibition of AblChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 81nMAssay Description:Inhibition of Abl T315I mutantChecked by AuthorMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 56nMAssay Description:Binding affinity to PDGFRAChecked by AuthorMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of cKITChecked by AuthorMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of SrcChecked by AuthorMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 93nMAssay Description:Inhibition of FGFR1Checked by AuthorMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 36nMAssay Description:Inhibition of VEGFR2Checked by AuthorMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Vertex Pharmaceuticals
Curated by ChEMBL
Vertex Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of Flt3Checked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:Inhibition of FAKChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 290nMAssay Description:Inhibition of aurora B kinaseChecked by AuthorMore data for this Ligand-Target Pair