BDBM50295154 2-(2,5-dichlorophenylamino)-2-oxoethyl 2-aminonicotinate::CHEMBL541696

SMILES Nc1ncccc1C(=O)OCC(=O)Nc1cc(Cl)ccc1Cl

InChI Key InChIKey=YMVSLWCLCVAZAN-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50295154   

TargetCruzipain(Trypanosoma cruzi)
University Of California

Curated by ChEMBL
LigandPNGBDBM50295154(2-(2,5-dichlorophenylamino)-2-oxoethyl 2-aminonico...)
Affinity DataKi:  3.20E+4nMAssay Description:Competitive inhibition of Trypanosoma cruzi cruzain by Lineaweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
University Of California

Curated by ChEMBL
LigandPNGBDBM50295154(2-(2,5-dichlorophenylamino)-2-oxoethyl 2-aminonico...)
Affinity DataIC50:  2.70E+4nMAssay Description:Inhibition of Trypanosoma cruzi cruzain preincubated for 5 mins before substrate addition in presence of 0.001% Triton X-100More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
University Of California

Curated by ChEMBL
LigandPNGBDBM50295154(2-(2,5-dichlorophenylamino)-2-oxoethyl 2-aminonico...)
Affinity DataIC50:  7.70E+4nMAssay Description:Inhibition of Trypanosoma cruzi cruzain preincubated for 5 mins before substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
University Of California

Curated by ChEMBL
LigandPNGBDBM50295154(2-(2,5-dichlorophenylamino)-2-oxoethyl 2-aminonico...)
Affinity DataIC50:  1.16E+5nMAssay Description:Inhibition of Trypanosoma cruzi cruzain preincubated for 5 mins before substrate addition in presence of 0.001% bovine serum albuminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
University Of California

Curated by ChEMBL
LigandPNGBDBM50295154(2-(2,5-dichlorophenylamino)-2-oxoethyl 2-aminonico...)
Affinity DataIC50:  2.70E+4nMAssay Description:Inhibition of Trypanosoma cruzi cruzain preincubated for 5 mins before substrate addition in presence of 0.01% Triton X-100More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed