BDBM50322180 3-(2,5-dimethylphenylsulfonyl)-N-isopropylthieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine::CHEMBL1172794::UT-A1 inhibitor D1

SMILES CC(C)Nc1nc2c(nnn2c2ccsc12)S(=O)(=O)c1cc(C)ccc1C

InChI Key InChIKey=TZKAXVMSVDWDPN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50322180   

TargetUrea transporter 2(Rattus norvegicus (Rat))
University of California San Francisco

LigandPNGBDBM50322180(3-(2,5-dimethylphenylsulfonyl)-N-isopropylthieno[2...)
Affinity DataIC50:  3.80E+3nMAssay Description:The urea concentration dependence of UT-A1 inhibition was studied from inhibitor concentration response data (0.3 - 60 µM) using different of ur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50322180(3-(2,5-dimethylphenylsulfonyl)-N-isopropylthieno[2...)
Affinity DataIC50:  350nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50322180(3-(2,5-dimethylphenylsulfonyl)-N-isopropylthieno[2...)
Affinity DataIC50:  28.3nMAssay Description:Binding affinity to human recombinant 5HT6 receptor expressed in HEK293 cells by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrea transporter 1(Rattus norvegicus (Rat))
University of California San Francisco

LigandPNGBDBM50322180(3-(2,5-dimethylphenylsulfonyl)-N-isopropylthieno[2...)
Affinity DataIC50:  1.50E+4nMAssay Description:Erythrocyte suspension (100 µL) was added to each well of a 96-well microplate to which test compounds were added. After 15 min incubation, 20 &...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed