BDBM50327939 7-methoxytacrine::CHEMBL1256415

SMILES COc1ccc2nc3CCCCc3c(N)c2c1

InChI Key InChIKey=APQPVVOYBLOJDY-UHFFFAOYSA-N

Data  4 KI  28 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50327939   

TargetAcetylcholinesterase(Homo sapiens (Human))
University Hospital Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human recombinant AChE assessed as reduction in cholinesterase activity using acetylthiocholine iodide as substrate by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
University Hospital Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataIC50:  1.76E+4nMAssay Description:Inhibition of human plasmatic BuChE assessed as reduction in cholinesterase activity by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
University Hospital Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of human GluN1a/GluN2A receptor expressed in HEK293 cells assessed as inhibition of glycine/glutamate-induced current measured at -60 mV h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-4(Rattus norvegicus (Rat))
University Hospital Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataIC50:  7.24E+3nMAssay Description:Inhibition of human GluN1a/GluN2B receptor expressed in HEK293 cells assessed as inhibition of glycine/glutamate-induced current measured at -60 mV h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
University Hospital Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataIC50:  4.93E+4nMAssay Description:Inhibition of human GluN1a/GluN2A receptor expressed in HEK293 cells assessed as relative inhibition of glycine/glutamate-induced current measured at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-4(Rattus norvegicus (Rat))
University Hospital Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50327939(7-methoxytacrine | CHEMBL1256415)
Affinity DataIC50:  5.10E+4nMAssay Description:Inhibition of human GluN1a/GluN2B receptor expressed in HEK293 cells assessed as relative inhibition of glycine/glutamate-induced current measured at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed