BDBM50382425 CHEMBL2022968
SMILES CN(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(CN3CCN(C)CC3)cc2)ncc1Cl
InChI Key InChIKey=YUAALFPUEOYPNX-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50382425
Affinity DataIC50: 12nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibition of human recombinant His-tagged AXL kinase using fluorescein-labelled poly-GT as substrate after 60 mins by TR-FRET analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of human Axl using KKSRGDYMTMQIG as substrate incubated for 40 mins in the presence of [gamma33P]ATP by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 305nMAssay Description:Inhibition of AXL-mediated AKT Ser473 phosphorylation in human PSN1 cells assessed as decrease in GAS6-induced phospho-AKT level after 2 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 222nMAssay Description:Inhibition of AXL in human PSN1 cells assessed as decrease in GAS6-induced phospho-AXL level after 2 hrs by EILSAMore data for this Ligand-Target Pair