BDBM50399039 CHEMBL2178814

SMILES CN(C)CC[C@H](N(C)C(=O)c1c(C)cc(cc1C)-c1cccc(NS(=O)(=O)c2cc(C)c(Cl)cc2C)c1)C(O)=O

InChI Key InChIKey=LDWAKTDSZSERFS-SANMLTNESA-N

Data  5 IC50  1 Kd  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50399039   

TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50399039(CHEMBL2178814)
Affinity DataKd:  0.670nMAssay Description:Competitive binding affinity to human S1P1R receptor expressed in CHO cell membranes by Schild plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50399039(CHEMBL2178814)
Affinity DataIC50:  978nMAssay Description:Antagonist activity at human S1P5R receptor expressed in CHO cell membranes by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50399039(CHEMBL2178814)
Affinity DataIC50:  802nMAssay Description:Antagonist activity at human S1P3R receptor expressed in CHO cell membranes by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50399039(CHEMBL2178814)
Affinity DataIC50:  3.40nMAssay Description:Antagonist activity at human S1P1R receptor expressed in CHO cell membranes by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50399039(CHEMBL2178814)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at human S1P4R receptor expressed in CHO cell membranes by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50399039(CHEMBL2178814)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human S1P1R receptor expressed in CHO cell membranes by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50399039(CHEMBL2178814)
Affinity DataEC50:  1.20E+3nMAssay Description:Agonist activity at human S1P4R receptor expressed in CHO cell membranes by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50399039(CHEMBL2178814)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human S1P5R receptor expressed in CHO cell membranes by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50399039(CHEMBL2178814)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human S1P3R receptor expressed in CHO cell membranes by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50399039(CHEMBL2178814)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human S1P2R receptor expressed in CHO cell membranes by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50399039(CHEMBL2178814)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at human S1P2R receptor expressed in CHO cell membranes by [35S]GTPgamma binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed