BDBM50431366 CHEMBL2347996

SMILES CC(C)(C)NC(=O)c1c[nH]c2ncc(nc12)-c1ncn2CCCCc12

InChI Key InChIKey=NEVNJCLJFXHCCC-UHFFFAOYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50431366   

TargetCytochrome P450 3A4(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50431366(CHEMBL2347996)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50431366(CHEMBL2347996)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50431366(CHEMBL2347996)
Affinity DataIC50:  26nMAssay Description:Inhibition of [3H]5-HT reuptake at serotonin transporter in rat mid brainMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50431366(CHEMBL2347996)
Affinity DataIC50:  634nMAssay Description:Inhibition of SYK in human whole bloodMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50431366(CHEMBL2347996)
Affinity DataIC50:  26nMAssay Description:Inhibition of human recombinant truncated SYK (360 to 365 amino acid residues) using N-terminally biotinylated EPEGDYEEVLE peptide as substrate asses...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50431366(CHEMBL2347996)
Affinity DataIC50:  450nMAssay Description:Inhibition of SYK in human Ramos cellsMore data for this Ligand-Target Pair