BDBM50465231 CHEMBL4288150::US10766903, Example 30

SMILES C[C@H](CC(=O)N1CCC(O)(Cn2cnc3c(-c4ccc(CN)cc4)n(C)nc3c2=O)CC1)c1ccccc1

InChI Key InChIKey=DGHAUZFDWIZFRM-HXUWFJFHSA-N

Data  6 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50465231   

TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Almac Discovery

Curated by ChEMBL
LigandPNGBDBM50465231(CHEMBL4288150 | US10766903, Example 30)
Affinity DataIC50:  6nMAssay Description:Inhibition of USP7 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Almac Discovery

Curated by ChEMBL
LigandPNGBDBM50465231(CHEMBL4288150 | US10766903, Example 30)
Affinity DataIC50: <250nMAssay Description:USP7 activity was monitored in a fluorescence polarisation (FP) homogeneous assay using the isopeptide ubiquitin-Lys-TAMRA substrate (U-558, Boston B...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Almac Discovery

Curated by ChEMBL
LigandPNGBDBM50465231(CHEMBL4288150 | US10766903, Example 30)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged full length USP7 expressed in baculovirus infected Sf21 cells using monoubiquitinated ubiquiti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Almac Discovery

Curated by ChEMBL
LigandPNGBDBM50465231(CHEMBL4288150 | US10766903, Example 30)
Affinity DataKd:  42nMAssay Description:Binding affinity to USP7 (208 to 560 residues) (unknown origin) assessed as dissociation constant by biolayer interferometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Almac Discovery

Curated by ChEMBL
LigandPNGBDBM50465231(CHEMBL4288150 | US10766903, Example 30)
Affinity DataKd:  53nMAssay Description:Binding affinity to human USP7 (208 to 560 residues) by SPR methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Almac Discovery

Curated by ChEMBL
LigandPNGBDBM50465231(CHEMBL4288150 | US10766903, Example 30)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human USP7 using Ub-Rho110 as substrate by fluorescence based SPR analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Almac Discovery

Curated by ChEMBL
LigandPNGBDBM50465231(CHEMBL4288150 | US10766903, Example 30)
Affinity DataKd:  4.71E+5nMAssay Description:Inhibition of human USP7 using Ub-Rho110 as substrate assessed as dissociation constant by fluorescence based SPR analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Almac Discovery

Curated by ChEMBL
LigandPNGBDBM50465231(CHEMBL4288150 | US10766903, Example 30)
Affinity DataIC50:  18nMAssay Description:Inhibition of full-length USP7 (unknown origin) using ubiquitin-rhodamine 110 as substrate preincubated for 30 mins followed by substrate addition an...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Almac Discovery

Curated by ChEMBL
LigandPNGBDBM50465231(CHEMBL4288150 | US10766903, Example 30)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human USP7 using Ub-Rho110 as substrate by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed