BDBM50509049 CHEMBL4440744
SMILES CCn1nc(C)cc1C(=O)\N=c1/[nH]c2cc(ccc2n1CCCCn1c2ccc(cc2[nH]\c1=N/C(=O)c1cc(C)nn1CC)C(N)=O)C(N)=O
InChI Key InChIKey=ICZSAXDKFXTSGL-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50509049
Affinity DataIC50: 20nMAssay Description:Inhibition of wild type human STING by SPA assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3.10E+3nMAssay Description:Inhibition of wild type human STING by SPA assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3.10E+3nMAssay Description:Induction of STING in human PBMC assessed as increase in IFNbeta secretionMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Zhejiang Normal University
Curated by ChEMBL
Zhejiang Normal University
Curated by ChEMBL
Affinity DataEC50: 5.39E+4nMAssay Description:Induction of TBK1 in human PBMC assessed as increase in cGAMP secretionMore data for this Ligand-Target Pair
Affinity DataKd: 1.60nMAssay Description:Binding affinity to human wild type STING assessed as dissociation constantMore data for this Ligand-Target Pair
Affinity DataEC50: 1.23E+3nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
Affinity DataKd: 1.60nMAssay Description:Binding affinity to human C-terminal domain STING (139 to 379 residues) assessed as dissociation constant by scanning fluorimetry assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Agonist activity to C-terminal domain human STING (139 to 379 residues)More data for this Ligand-Target Pair
Affinity DataEC50: 3.10E+3nMAssay Description:Agonist activity to C-terminal domain STING (139 to 379 residues) in human PBMC assessed as IFN-beta secretionMore data for this Ligand-Target Pair
Affinity DataIC50: 6.20nMAssay Description:Binding affinity to recombinant human His-tagged STING by measuring fluorescent signals in the presence of d2 labelled STING wild type ligand by HTRF...More data for this Ligand-Target Pair
Affinity DataEC50: 3.10E+3nMAssay Description:Agonist activity at human wild type STINGMore data for this Ligand-Target Pair