BDBM50554817 CHEMBL4764610
SMILES COc1cc2c(c(F)c1N1C[C@H](C)N(C)[C@H](C)C1)n(C(C)C)c1[nH]c3cc(ccc3c1c2=O)C#N
InChI Key InChIKey=LOONVQWRKJLEEG-IYBDPMFKSA-N
Data 18 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 18 hits for monomerid = 50554817
Affinity DataIC50: 2.20nMAssay Description:Inhibition of N-terminal GST tagged wild-type human ALK cytoplasmic domain (1058-1620 amino acids) expressed Sf9 cells pre-incubated for 30 mins befo...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of human ROS1More data for this Ligand-Target Pair
Affinity DataIC50: 6.30nMAssay Description:Inhibition of human ALK L1196M mutant expressed Sf9 cells pre-incubated for 30 mins before addition of Ulight-CKKSRGDYMTMQIG substrate and measured a...More data for this Ligand-Target Pair
Affinity DataIC50: 8.90nMAssay Description:Inhibition of human ALK S1206Y mutant expressed Sf9 cells pre-incubated for 30 mins before addition of Ulight-CKKSRGDYMTMQIG substrate and measured a...More data for this Ligand-Target Pair
Affinity DataIC50: 5.60nMAssay Description:Inhibition of human ALKMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human ALK C1156Y mutantMore data for this Ligand-Target Pair
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human ALK L1196M mutantMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Inhibition of human CLK1More data for this Ligand-Target Pair
TargetDeath-associated protein kinase 1(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibition of human DAPK1More data for this Ligand-Target Pair
TargetDeath-associated protein kinase 2(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of human DAPK2More data for this Ligand-Target Pair
TargetDeath-associated protein kinase 3(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataIC50: 260nMAssay Description:Inhibition of human DAPK3More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of human FAKMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
Affinity DataIC50: 950nMAssay Description:Inhibition of human INSRMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human INSRRMore data for this Ligand-Target Pair
TargetLeukocyte tyrosine kinase receptor(Homo sapiens (Human))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataIC50: 6.30nMAssay Description:Inhibition of human LTKMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of human MERTKMore data for this Ligand-Target Pair
Affinity DataIC50: 8.80nMAssay Description:Inhibition of human ALK G1269A mutant expressed Sf9 cells pre-incubated for 30 mins before addition of Ulight-CKKSRGDYMTMQIG substrate and measured a...More data for this Ligand-Target Pair