BDBM50572481 CHEMBL4866156

SMILES COc1cc2CCN(CCc3ccc(cc3)-n3nnc(n3)-c3cc(OC)c(OC)cc3NC(=O)c3cc(=O)c4c(OC)cccc4o3)Cc2cc1OC

InChI Key InChIKey=XYLWMOIQRWOPOJ-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50572481   

TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Athenex

Curated by ChEMBL
LigandPNGBDBM50572481(CHEMBL4866156)
Affinity DataEC50:  5.90nMAssay Description:Inhibition of P-gp (unknown origin) expressed in MES-SA/DX5 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Athenex

Curated by ChEMBL
LigandPNGBDBM50572481(CHEMBL4866156)
Affinity DataEC50:  7.40nMAssay Description:Inhibition of P-gp (unknown origin) expressed in MCF7 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed