BDBM521551 2-Ethylbutyl ((((2S,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-2-fluoro-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-D-alaninate::US11149049, No. 9
SMILES CCC(CC)COC(=O)[C@@H](C)NP(=O)(OC[C@@]1(F)O[C@](C#N)([C@H](O)[C@@H]1O)c1ccc2c(N)ncnn12)Oc1ccccc1
InChI Key InChIKey=KOJGIIGOWLMIGC-NTNFTGTCSA-N
Data 5 EC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 521551
TargetEnvelope glycoprotein(Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zair...)
Janssen Biopharma
US Patent
Janssen Biopharma
US Patent
Affinity DataEC50: 250nMAssay Description:HEp-2 cells were plated in 96-well plates at the density of 40,000 cells/well. On the next day, modified vaccinia virus Ankara-T7 (MVA-T7) at the mul...More data for this Ligand-Target Pair
Affinity DataEC50: 130nMAssay Description:HeLa-OHIO cells (Sigma-Aldrich, St. Louis, Mo.) were plated in 96 well plates at a density of 1.5×105 cells per well in assay media (MEM without phen...More data for this Ligand-Target Pair
TargetRous sarcoma virus integrase(Rous sarcoma virus (strain Prague C) (RSV-PrC))
Janssen Biopharma
US Patent
Janssen Biopharma
US Patent
Affinity DataEC50: 18nMAssay Description:The HeLa-derived cells containing the stable RSV replicon were cultured in DMEM containing 4500 mg/L D-glucose, L-glutamine, and 110 mg/L sodium pyru...More data for this Ligand-Target Pair
Affinity DataEC50: 70nMAssay Description:The Dengue virus type 2 strain New Guniea C (NG-C) and the Dengue virus type 4 strain H241 were purchased from ATCC (Manassas, Va.; item numbers VR-1...More data for this Ligand-Target Pair
Affinity DataEC50: 25nMAssay Description:The human β-coronavirus strain OC43 was purchased from ATCC (Manassas, Va.; item numbers VR-1558 and VR-740, respectively). 24 hours prior to do...More data for this Ligand-Target Pair