BDBM62527 (3,5-Dimethyl-pyrazol-1-yl)-pyridin-4-yl-methanone::(3,5-dimethyl-1-pyrazolyl)-pyridin-4-ylmethanone::(3,5-dimethylpyrazol-1-yl)-(4-pyridyl)methanone::(3,5-dimethylpyrazol-1-yl)-pyridin-4-yl-methanone::(3,5-dimethylpyrazol-1-yl)-pyridin-4-ylmethanone::MLS000029407::SMR000012020::cid_645025

SMILES Cc1cc(C)n(n1)C(=O)c1ccncc1

InChI Key InChIKey=VXESXFNPRURVHH-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 62527   

TargetHeat shock factor protein 1(Mus musculus)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM62527((3,5-Dimethyl-pyrazol-1-yl)-pyridin-4-yl-methanone...)
Affinity DataEC50: >1.95E+5nMAssay Description:Keywords: Heat Shock Factor-1 (HSF-1), Stress Response, MG132, NIH3T3, Luminescence Assay Overview: Modified NIH3T3, transformed to express firefly...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Homo sapiens (Human))
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM62527((3,5-Dimethyl-pyrazol-1-yl)-pyridin-4-yl-methanone...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human NPP1 expressed in COS7 cells using p-nitrophenyl-5'-thymidine monophosphate as substrate preincubated for 5 to 10 mins followed b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM62527((3,5-Dimethyl-pyrazol-1-yl)-pyridin-4-yl-methanone...)
Affinity DataIC50:  1.54E+3nMAssay Description:Inhibition of human IAP expressed in COS7 cells using CDP-star as substrate preincubated for 5 to 10 mins followed by substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEctonucleoside triphosphate diphosphohydrolase 1(Rattus norvegicus)
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM62527((3,5-Dimethyl-pyrazol-1-yl)-pyridin-4-yl-methanone...)
Affinity DataIC50:  4.76E+4nMAssay Description:Inhibition of rat NTPDase1 expressed in CHO cells using ATP as substrate preincubated for 10 mins followed by substrate addition measured after 10 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 3(Homo sapiens (Human))
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM62527((3,5-Dimethyl-pyrazol-1-yl)-pyridin-4-yl-methanone...)
Affinity DataIC50:  350nMAssay Description:Inhibition of human NPP3 expressed in COS7 cells using p-nitrophenyl-5'-thymidine monophosphate as substrate preincubated for 5 to 10 mins followed b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Homo sapiens (Human))
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM62527((3,5-Dimethyl-pyrazol-1-yl)-pyridin-4-yl-methanone...)
Affinity DataIC50:  6.51E+3nMAssay Description:Inhibition of human TNAP expressed in COS7 cells using CDP-star as substrate preincubated for 5 to 10 mins followed by substrate addition measured af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed