BDBM629369 US20230339981, Example 53::US20240025919, Compound 7

SMILES C[C@@H]1Oc2nc(c(F)c3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@H]5CC[C@H](N5)[C@@H]14)c23)-c1cc(O)cc2ccc(F)c(C#C)c12

InChI Key InChIKey=BKBSLIGISZMYGP-WFLMJTLHSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 629369   

TargetGTPase KRas [G12D](Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM629369(US20230339981, Example 53 | US20240025919, Compoun...)
Affinity DataIC50:  0.100nMAssay Description:Compounds were tested for binding to GDP-loaded KRAS G12D in a 384-well assay format using a TR-FRET probe displacement assay in buffer consisting of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [G12D](Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM629369(US20230339981, Example 53 | US20240025919, Compoun...)
Affinity DataIC50:  0.0590nMAssay Description:Biochemical compound potencies are assessed by evaluating inhibition of SOS1I-mediated nucleotide exchange in KRAS G121D. In this assay, the SOS1-pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM629369(US20230339981, Example 53 | US20240025919, Compoun...)
Affinity DataIC50:  0.296nMAssay Description:Biochemical compound potencies are assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS WT. In this assay, the SOS1-promote...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent