BDBM629369 US20230339981, Example 53::US20240025919, Compound 7
SMILES C[C@@H]1Oc2nc(c(F)c3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4C[C@H]5CC[C@H](N5)[C@@H]14)c23)-c1cc(O)cc2ccc(F)c(C#C)c12
InChI Key InChIKey=BKBSLIGISZMYGP-WFLMJTLHSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 629369
Affinity DataIC50: 0.100nMAssay Description:Compounds were tested for binding to GDP-loaded KRAS G12D in a 384-well assay format using a TR-FRET probe displacement assay in buffer consisting of...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0590nMAssay Description:Biochemical compound potencies are assessed by evaluating inhibition of SOS1I-mediated nucleotide exchange in KRAS G121D. In this assay, the SOS1-pro...More data for this Ligand-Target Pair
Affinity DataIC50: 0.296nMAssay Description:Biochemical compound potencies are assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS WT. In this assay, the SOS1-promote...More data for this Ligand-Target Pair