BDBM66431 2-(3-chloro-N-(2-chloro-1-oxoethyl)-4-methoxyanilino)-N-(2-phenylethyl)-2-thiophen-2-ylacetamide::2-(3-chloro-N-(2-chloroacetyl)-4-methoxy-anilino)-N-phenethyl-2-(2-thienyl)acetamide::2-(3-chloro-N-(2-chloroacetyl)-4-methoxyanilino)-N-(2-phenylethyl)-2-thiophen-2-ylacetamide::2-[(chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide::2-[2-chloranylethanoyl-(3-chloranyl-4-methoxy-phenyl)amino]-N-(2-phenylethyl)-2-thiophen-2-yl-ethanamide::MLS000583955::SMR000206941::cid_3689413

SMILES COc1ccc(cc1Cl)N(C(C(=O)NCCc1ccccc1)c1cccs1)C(=O)CCl

InChI Key InChIKey=UNVKYJSNMVDZJE-UHFFFAOYSA-N

Data  2 IC50  3 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 66431   

TargetBcl-2-like protein 11(Homo sapiens (Human))
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM66431(2-(3-chloro-N-(2-chloro-1-oxoethyl)-4-methoxyanili...)
Affinity DataEC50:  7.06E+4nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM66431(2-(3-chloro-N-(2-chloro-1-oxoethyl)-4-methoxyanili...)
Affinity DataIC50:  25nMAssay Description:Inhibition of Vps34 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipid hydroperoxide glutathione peroxidase(Homo sapiens)
Institute Of Mit And Harvard

Curated by ChEMBL
LigandPNGBDBM66431(2-(3-chloro-N-(2-chloro-1-oxoethyl)-4-methoxyanili...)
Affinity DataEC50:  2.20E+3nMAssay Description:Inhibition of GPX4 in human LOX IMVI cells assessed as ferroptosis-mediated cell death measured as cell viability in presence of ferrostatin-1More data for this Ligand-Target Pair
TargetPhospholipid hydroperoxide glutathione peroxidase(Homo sapiens)
Institute Of Mit And Harvard

Curated by ChEMBL
LigandPNGBDBM66431(2-(3-chloro-N-(2-chloro-1-oxoethyl)-4-methoxyanili...)
Affinity DataEC50:  28nMAssay Description:Inhibition of GPX4 in human LOX IMVI cells assessed as ferroptosis-mediated cell death measured as cell viabilityMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM66431(2-(3-chloro-N-(2-chloro-1-oxoethyl)-4-methoxyanili...)
Affinity DataIC50:  18nMAssay Description:Inhibition of Vps34 (unknown origin) interaction with PIK3 assessed as reduction in autophagy by increasing LC3 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed