BDBM86521 CAS_5719::NSC_5719::Zaleplon

SMILES CCN(C(C)=O)c1cccc(c1)-c1ccnc2c(cnn12)C#N

InChI Key InChIKey=HUNXMJYCHXQEGX-UHFFFAOYSA-N

Data  5 KI  4 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 86521   

TargetGamma-aminobutyric acid receptor subunit alpha-1(Rattus norvegicus (Rat))
Neurocrine Biosciences

Curated by PDSP Ki Database
LigandPNGBDBM86521(CAS_5719 | NSC_5719 | Zaleplon)
Affinity DataKi:  45.5nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rattus norvegicus (Rat))
Neurocrine Biosciences

Curated by PDSP Ki Database
LigandPNGBDBM86521(CAS_5719 | NSC_5719 | Zaleplon)
Affinity DataKi:  59.8nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rattus norvegicus (Rat))
Neurocrine Biosciences

Curated by PDSP Ki Database
LigandPNGBDBM86521(CAS_5719 | NSC_5719 | Zaleplon)
Affinity DataKi:  68.5nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rattus norvegicus (Rat))
Neurocrine Biosciences

Curated by PDSP Ki Database
LigandPNGBDBM86521(CAS_5719 | NSC_5719 | Zaleplon)
Affinity DataKi:  81.2nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldehyde oxidase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM86521(CAS_5719 | NSC_5719 | Zaleplon)
Affinity DataKi:  8.30E+4nMAssay Description:Inhibition of aldehyde oxidase in human liver cytosol assessed as production of oxozoniporideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM86521(CAS_5719 | NSC_5719 | Zaleplon)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM86521(CAS_5719 | NSC_5719 | Zaleplon)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM86521(CAS_5719 | NSC_5719 | Zaleplon)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM86521(CAS_5719 | NSC_5719 | Zaleplon)
Affinity DataEC50: >1.00E+3nMAssay Description:Modulation of human GABAA alpha3beta3gamma2 expressed in xenopus oocytes assessed as potentiation of GABA-evoked chloride currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM86521(CAS_5719 | NSC_5719 | Zaleplon)
Affinity DataEC50:  290nMAssay Description:Modulation of human GABA-A alpha1beta2gamma2 expressed in xenopus oocytes assessed as potentiation of GABA-evoked chloride currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM86521(CAS_5719 | NSC_5719 | Zaleplon)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM86521(CAS_5719 | NSC_5719 | Zaleplon)
Affinity DataEC50:  1.63E+3nMAssay Description:Modulation of human GABAA alpha2beta3gamma2 expressed in xenopus oocytes assessed as potentiation of GABA-evoked chloride currentsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed