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Found 1550 with Last Name = 'ciblat' and Initial = 's'
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591018(CHEMBL5204203)
Affinity DataIC50:  0.0680nMAssay Description:Inhibition of human DNA polymerase theta pol domain (1819 to 2590 residues) expressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591016(CHEMBL5175156)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human DNA polymerase theta pol domain (1819 to 2590 residues) expressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM635953((1R,2S)-2-(3-((5-chloro-6-(1,1-dioxidothiomorpholi...)
Affinity DataIC50:  0.350nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM635903((1R,2S)-2-(3-{[(3S)-3-hydroxy-2,3-dihydro-1-benzof...)
Affinity DataIC50:  0.375nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591017(CHEMBL5206022)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human DNA polymerase theta pol domain (1819 to 2590 residues) expressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM635951((1R,2S)-2-(3-{[5-chloro-2-cyclopropyl-6-(3-hydroxy...)
Affinity DataIC50:  0.434nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM50073587(CHEMBL3408947 | US10358436, Example A185 | US20230...)
Affinity DataIC50:  0.496nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591022(CHEMBL5197367)
Affinity DataIC50:  0.510nMAssay Description:Inhibition of human DNA polymerase theta pol domain (1819 to 2590 residues) expressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591035(CHEMBL5187422)
Affinity DataIC50:  0.550nMAssay Description:Inhibition of N-terminal His8-tagged/C-terminal FLAG-tagged full length human DNA polymerase theta ( 1 to 2590 residues) polymerase activity expresse...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636141(5-methoxy-6-({6-[(1R,2S)-5'-methoxy-2'-oxo-1',2'-d...)
Affinity DataIC50:  0.564nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636146(5-ethoxy-6-({6-[(1R,2S)-5'-methoxy-2'-oxo-1',2'-di...)
Affinity DataIC50:  0.590nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636134((1R,2S)-2-(3-{[5-(azetidine-1-carbonyl)-3-methoxyp...)
Affinity DataIC50:  0.650nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636127((1R,2S)-5'-methoxy-2-(3-{[3-methoxy-5-(8-oxa-3-aza...)
Affinity DataIC50:  0.650nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM635884((1R,2S)-2-(3-{[5-chloro-6-(morpholin-4-yl)pyrimidi...)
Affinity DataIC50:  0.694nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636070((1R,2S)-5'-methoxy-2-{3-[2-methoxy-4-(morpholine-4...)
Affinity DataIC50:  0.716nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591030(CHEMBL5174509)
Affinity DataIC50:  0.720nMAssay Description:Inhibition of human DNA polymerase theta pol domain (1819 to 2590 residues) expressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636116((1R,2S)-2-[3-({6-[(2R,6S)-2,6-dimethylpiperidine-1...)
Affinity DataIC50:  0.738nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591026(CHEMBL5197173)
Affinity DataIC50:  0.75nMAssay Description:Inhibition of human DNA polymerase theta pol domain (1819 to 2590 residues) expressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636145((1R,2S)-2-(3-{[5-(ethanesulfonyl)-3-ethoxypyridin-...)
Affinity DataIC50:  0.763nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636135((1R,2S)-5'-methoxy-2-(3-{[3-methoxy-5-(morpholine-...)
Affinity DataIC50:  0.785nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636037(6-methoxy-5-({6-[(1R,2S)-5'-methoxy-2'-oxo-1',2'-d...)
Affinity DataIC50:  0.802nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636149((1R,2S)-2-(3-{[6-(2-hydroxypropan-2-yl)-3-methoxyp...)
Affinity DataIC50:  0.804nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636077(2-fluoro-5-methoxy-4-({6-[(1R,2S)-5'-methoxy-2'-ox...)
Affinity DataIC50:  0.806nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636075(5-methoxy-6-({6-[(1R,2S)-5'-methoxy-2'-oxo-1',2'-d...)
Affinity DataIC50:  0.810nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591015(CHEMBL5170373)
Affinity DataIC50:  0.820nMAssay Description:Inhibition of human DNA polymerase theta pol domain (1819 to 2590 residues) expressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM635997((1R,2S)-5'-methoxy-2-(3-{[5-methoxy-2-(propan-2-yl...)
Affinity DataIC50:  0.833nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636143((1R,2S)-2-{3-[2-ethoxy-4-(methanesulfonyl)anilino]...)
Affinity DataIC50:  0.833nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636117((1R,2S)-5'-methoxy-2-(3-{[2-methoxy-6-(8-oxa-3-aza...)
Affinity DataIC50:  0.843nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636139((1R,2S)-2-(3-{[5-(azetidine-1-sulfonyl)-3-methoxyp...)
Affinity DataIC50:  0.874nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636140(5-methoxy-6-({6-[(1R,2S)-5'-methoxy-2'-oxo-1',2'-d...)
Affinity DataIC50:  0.890nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636079((1R,2S)-2-{3-[5-fluoro-2-methoxy-4-(morpholine-4-c...)
Affinity DataIC50:  0.897nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591028(CHEMBL5194637)
Affinity DataIC50:  0.910nMAssay Description:Inhibition of human DNA polymerase theta pol domain (1819 to 2590 residues) expressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636078((1R,2S)-2-{3-[5-fluoro-2-methoxy-4-(morpholine-4-c...)
Affinity DataIC50:  0.952nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636089(N,6-dimethoxy-5-({6-[(1R,2S)-5'-methoxy-2'-oxo-1',...)
Affinity DataIC50:  0.955nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636065(6-methoxy-5-({6-[(1R,2S)-5'-methoxy-2'-oxo-1',2'-d...)
Affinity DataIC50:  0.965nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636130((1R,2S)-5'-methoxy-2-(3-{[3-methoxy-5-(oxane-4-sul...)
Affinity DataIC50:  0.971nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636026((1R,2S)-5'-methoxy-2-(3-{[5-methoxy-2-(oxan-4-yl)p...)
Affinity DataIC50:  0.976nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA polymerase theta(Homo sapiens)
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50591027(CHEMBL5197021)
Affinity DataIC50:  0.990nMAssay Description:Inhibition of human DNA polymerase theta pol domain (1819 to 2590 residues) expressed in Escherichia coli BL21 (DE3) cells preincubated for 15 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636040((1R,2S)-2-[3-({2-[(3R)-3-fluoropyrrolidin-1-yl]-5-...)
Affinity DataIC50:  0.995nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM635947((1R,2S)-2-(3-{[5-chloro-6-(3-hydroxyazetidin-1-yl)...)
Affinity DataIC50:  0.997nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636085(6-ethoxy-5-({6-[(1R,2S)-5'-methoxy-2'-oxo-1',2'-di...)
Affinity DataIC50:  1.01nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636027((1R,2S)-5'-methoxy-2-(3-{[5-methoxy-2-(methylsulfa...)
Affinity DataIC50:  1.03nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636103((1R,2S)-5'-methoxy-2-(3-{[2-methoxy-6-(3-oxa-8-aza...)
Affinity DataIC50:  1.03nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636060((1R,2S)-2-(3-{[2-(4,4-difluoropiperidin-1-yl)-5-me...)
Affinity DataIC50:  1.04nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636074(5-ethoxy-6-({6-[(1R,2S)-5'-methoxy-2'-oxo-1',2'-di...)
Affinity DataIC50:  1.04nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636068(5-methoxy-6-({6-[(1R,2S)-5'-methoxy-2'-oxo-1',2'-d...)
Affinity DataIC50:  1.08nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM635945((1R,2S)-2-(3-((5-chloro-2-cyclopropyl-6-(1,1-dioxi...)
Affinity DataIC50:  1.10nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636064((1R,2S)-2-(3-{[5-(methanesulfonyl)-3-methoxypyridi...)
Affinity DataIC50:  1.13nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM635972((1R,2S)-5'-methoxy-2-(3-{[5-methoxy-2-(morpholin-4...)
Affinity DataIC50:  1.14nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636114(N,N-dicyclopropyl-6-methoxy-5-({6-[(1R,2S)-5'-meth...)
Affinity DataIC50:  1.15nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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