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Found 333 with Last Name = 'claiborne' and Initial = 'a'
TargetTubulin beta-2B chain(Bos taurus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Affinity DataKi:  180nMAssay Description:Binding constant at colchicine site of bovine brain tubulinMore data for this Ligand-Target Pair
TargetTubulin beta-2B chain(Bos taurus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50109343(1-Methyl-5-[(S)-5-(3,4,5-trimethoxy-phenyl)-4,5-di...)
Affinity DataKi:  630nMAssay Description:Binding constant at colchicine site of bovine brain tubulinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTubulin beta-2B chain(Bos taurus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50014846((S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-...)
Affinity DataKi:  780nMAssay Description:Binding constant at colchicine site of bovine brain tubulinMore data for this Ligand-Target Pair
TargetTubulin beta-2B chain(Bos taurus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50109342(1-Methyl-5-[(R)-5-(3,4,5-trimethoxy-phenyl)-4,5-di...)
Affinity DataKi:  3.69E+3nMAssay Description:Binding constant at colchicine site of bovine brain tubulinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTubulin beta-2B chain(Bos taurus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50012278((2ALPHA,2''BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLAS...)
Affinity DataKi: >1.00E+5nMAssay Description:Binding constant at colchicine site of bovine brain tubulinMore data for this Ligand-Target Pair
LigandPNGBDBM14453(1-({1-[(4-cyanophenyl)methyl]-1H-imidazol-5-yl}met...)
Affinity DataIC50:  0.150nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50212488(4'-{7-methoxy-6-[(2-pyrrolidin-1-yl-ethylamino)-me...)
Affinity DataIC50:  0.210nMAssay Description:Inhibition of recombinant CHK-mediated Cdc25C phosphorylation after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50212496(3-(4'-hydroxy-biphenyl-4-yl)-7-methoxy-1,4-dihydro...)
Affinity DataIC50:  0.240nMAssay Description:Inhibition of recombinant CHK-mediated Cdc25C phosphorylation after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50212497(CHEMBL234868 | [3-(4'-hydroxy-biphenyl-4-yl)-7-met...)
Affinity DataIC50:  0.240nMAssay Description:Inhibition of recombinant CHK-mediated Cdc25C phosphorylation after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153786(4-((5-((4-cyanophenoxy)methyl)-1H-imidazol-1-yl)me...)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of bovine farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153802(3'',4''-Dichloro-6-[3-(4-cyano-benzyl)-3H-imidazol...)
Affinity DataIC50:  0.370nMAssay Description:Inhibition of bovine farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153166(3''-Chloro-6-[3-(4-cyano-benzyl)-3H-imidazol-4-ylm...)
Affinity DataIC50:  0.370nMAssay Description:Inhibition of bovine farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153785(4-((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)-2-...)
Affinity DataIC50:  0.380nMAssay Description:Inhibition of bovine farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50212502(4'-{6-[(2-hydroxy-ethylamino)-methyl]-7-methoxy-1,...)
Affinity DataIC50:  0.430nMAssay Description:Inhibition of recombinant CHK-mediated Cdc25C phosphorylation after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153176(4''-tert-Butyl-6-[3-(4-cyano-benzyl)-3H-imidazol-4...)
Affinity DataIC50:  0.440nMAssay Description:Inhibition of bovine farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153172(6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)
Affinity DataIC50:  0.490nMAssay Description:Inhibition of bovine farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50212505(4'-[7-methoxy-6-(4-methyl-piperazin-1-ylmethyl)-1,...)
Affinity DataIC50:  0.510nMAssay Description:Inhibition of recombinant CHK-mediated Cdc25C phosphorylation after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50212516(CHEMBL232808 | [3-(4'-hydroxy-biphenyl-4-yl)-7-met...)
Affinity DataIC50:  0.550nMAssay Description:Inhibition of recombinant CHK-mediated Cdc25C phosphorylation after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50212484(4'-{6-[(4-hydroxy-cyclohexylamino)-methyl]-7-metho...)
Affinity DataIC50:  0.560nMAssay Description:Inhibition of recombinant CHK-mediated Cdc25C phosphorylation after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153776(5-((5-(((5-cyano-3'-ethoxybiphenyl-2-yl)methoxy)me...)
Affinity DataIC50:  0.580nMAssay Description:Inhibition of bovine farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14450(1-({1-[(4-cyanophenyl)methyl]-1H-imidazol-5-yl}met...)
Affinity DataIC50:  0.580nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50153782(6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of bovine farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153779(4-((5-(((3',5-dichlorobiphenyl-2-yl)methoxy)methyl...)
Affinity DataIC50:  0.620nMAssay Description:Inhibition of bovine farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50126335(6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...)
Affinity DataIC50:  0.650nMAssay Description:Inhibition of bovine farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

LigandPNGBDBM50126335(6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...)
Affinity DataIC50:  0.650nMAssay Description:Inhibition of Bovine farnesyltransferase (FTase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

LigandPNGBDBM50153774(4-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methylamin...)
Affinity DataIC50:  0.650nMAssay Description:Inhibition of bovine farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153174(6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)
Affinity DataIC50:  0.650nMAssay Description:Inhibition of bovine farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14434(6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl...)
Affinity DataIC50:  0.650nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50212491(CHEMBL234656 | N-[3-(4'-hydroxy-biphenyl-4-yl)-1,4...)
Affinity DataIC50:  0.740nMAssay Description:Inhibition of recombinant CHK-mediated Cdc25C phosphorylation after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50220766(5-(7-(4-morpholinobutoxy)-1,4-dihydroindeno[1,2-c]...)
Affinity DataIC50:  0.75nMAssay Description:Inhibition of recombinant CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM16958(6-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]-2-eth...)
Affinity DataIC50:  0.800nMpH: 7.5 T: 2°CAssay Description:The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153784(3-(benzo[d][1,3]dioxol-4-yl)-4-(((1-(4-cyanobenzyl...)
Affinity DataIC50:  0.810nMAssay Description:Inhibition of bovine farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50220753(5-(6,7-dimethoxy-1,4-dihydro-indeno[1,2-c]pyrazol-...)
Affinity DataIC50:  0.810nMAssay Description:Inhibition of recombinant CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50212503(3-(4'-hydroxy-biphenyl-4-yl)-7-methoxy-1,4-dihydro...)
Affinity DataIC50:  0.830nMAssay Description:Inhibition of recombinant CHK-mediated Cdc25C phosphorylation after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153778(6-((1-(4-cyano-3-(naphthalen-1-yl)benzyl)-1H-imida...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of bovine farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153777(4-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)
Affinity DataIC50:  0.920nMAssay Description:Inhibition of bovine farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50220762(5-(7-(3-(1,4-oxazepan-4-yl)propoxy)-1,4-dihydroind...)
Affinity DataIC50:  0.920nMAssay Description:Inhibition of recombinant CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14452(4-[(5-{[5-(naphthalen-1-yl)-1H-indol-1-yl]methyl}-...)
Affinity DataIC50:  0.930nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153781(4-((5-((4-cyanobenzyloxy)methyl)-1H-imidazol-1-yl)...)
Affinity DataIC50:  0.960nMAssay Description:Inhibition of bovine farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50220751(5-(7-(3-((2S,6R)-2,6-dimethylmorpholino)propoxy)-1...)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50220757(5-(7-(3-(piperidin-4-yl)propoxy)-1,4-dihydroindeno...)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Abbott Laboratories

LigandPNGBDBM16958(6-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]-2-eth...)
Affinity DataIC50:  1nMpH: 7.5 T: 2°CAssay Description:The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50212519(1-[3-(4'-hydroxy-biphenyl-4-yl)-7-methoxy-1,4-dihy...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of recombinant CHK-mediated Cdc25C phosphorylation after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50220768(5-(7-(3-(1H-imidazol-1-yl)propoxy)-1,4-dihydroinde...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of recombinant CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50220755(5-(6-methoxy-7-(2-(4-methylthiazol-5-yl)ethoxy)-1,...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of recombinant CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50220774(5-(7-(4-morpholinobutyl)-1,4-dihydroindeno[1,2-c]p...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of recombinant CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50212514(CHEMBL234654 | N-[3-(4'-hydroxy-biphenyl-4-yl)-1,4...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of recombinant CHK-mediated Cdc25C phosphorylation after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153165(6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of bovine farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153793(4-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of bovine farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153792(4''-Acetyl-6-[3-(4-cyano-benzyl)-3H-imidazol-4-ylm...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of bovine farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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