Affinity DataKi: 0.700nMAssay Description:Binding affinity to Sigma opioid receptor type 1 in guinea pig brain homogenate with 0.5 nM of [3H](+)-PENT as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 4.5nMAssay Description:Binding affinity to Sigma opioid receptor type 2 in guinea pig brain homogenate with 4 nM of [3H](+)-DTG as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 11nMAssay Description:Inhibition of human GLO1More data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Inhibition of human GLO1More data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
Affinity DataKi: 40nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
Affinity DataKi: 50nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
Affinity DataKi: 100nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
Affinity DataKi: 170nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
Affinity DataKi: 180nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
Affinity DataKi: 190nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
Affinity DataKi: 220nMAssay Description:Compound was evaluated for its inhibitory constant against 3-dehydroquinate synthaseMore data for this Ligand-Target Pair
Affinity DataKi: 230nMAssay Description:Inhibition of human GLO1More data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Binding affinity to human Zn2+-HDAC8 assessed as loss of activity by Fluor-de-Lys activity assayMore data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Compound was tested for inhibitory activity against FK506 binding protein 12 (FKBP12)More data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Boston University School Of Medicine
Curated by ChEMBL
Boston University School Of Medicine
Curated by ChEMBL
Affinity DataKi: 300nMAssay Description:Inhibition of Clostridium botulinum BoNT/A using SNAP-25 (141-206) as substrate by HPLC analysisMore data for this Ligand-Target Pair
Affinity DataKi: 1.00E+3nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Boston University School Of Medicine
Curated by ChEMBL
Boston University School Of Medicine
Curated by ChEMBL
Affinity DataKi: 2.00E+3nMAssay Description:Irreversible inhibition of Clostridium botulinum BoNT/A light chain expressed in Escherichia coli BL21 (DE3) using SNAPtide flp6 as substrate preincu...More data for this Ligand-Target Pair
Affinity DataKi: 2.36E+3nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
Affinity DataKi: 2.78E+3nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
Affinity DataKi: 3.17E+3nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
Affinity DataKi: 4.90E+3nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
Affinity DataKi: 7.00E+3nMAssay Description:Reversible-time dependent inhibition of human wild type HDAC8 by Fluor-de-Lys activity assayMore data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Boston University School Of Medicine
Curated by ChEMBL
Boston University School Of Medicine
Curated by ChEMBL
Affinity DataKi: 7.70E+3nMAssay Description:Irreversible inhibition of recombinant Clostridium botulinum N-terminal 6His-tagged BoNT/A (Met1 to Phe425 residues) catalytic domain expressed in Es...More data for this Ligand-Target Pair
Affinity DataKi: 8.82E+3nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Boston University School Of Medicine
Curated by ChEMBL
Boston University School Of Medicine
Curated by ChEMBL
Affinity DataKi: 8.90E+3nMAssay Description:Irreversible inhibition of Clostridium botulinum BoNT/A light chain expressed in Escherichia coli BL21 (DE3) using SNAPtide flp6 as substrate preincu...More data for this Ligand-Target Pair
Affinity DataKi: 1.40E+4nMAssay Description:Inhibition of human carbonic anhydrase using p-nitrophenylacetate as substrate preincubated for 10 mins before substrate addition by spectrophotometr...More data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Boston University School Of Medicine
Curated by ChEMBL
Boston University School Of Medicine
Curated by ChEMBL
Affinity DataKi: 1.70E+4nMAssay Description:Time dependent inhibition of Clostridium botulinum BoNT/A light chain expressed in Escherichia coli BL21 (DE3) using SNAPtide flp6 as substrate by me...More data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Boston University School Of Medicine
Curated by ChEMBL
Boston University School Of Medicine
Curated by ChEMBL
Affinity DataKi: 3.20E+4nMAssay Description:Time dependent inhibition of Clostridium botulinum BoNT/A light chain expressed in Escherichia coli BL21 (DE3) using SNAPtide flp6 as substrate by me...More data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Boston University School Of Medicine
Curated by ChEMBL
Boston University School Of Medicine
Curated by ChEMBL
Affinity DataKi: 3.80E+4nMAssay Description:Time dependent inhibition of Clostridium botulinum BoNT/A light chain expressed in Escherichia coli BL21 (DE3) using SNAPtide flp6 as substrate by me...More data for this Ligand-Target Pair
Affinity DataKi: 3.80E+4nMAssay Description:Inhibition of human carbonic anhydrase using p-nitrophenylacetate as substrate preincubated for 10 mins before substrate addition by spectrophotometr...More data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Boston University School Of Medicine
Curated by ChEMBL
Boston University School Of Medicine
Curated by ChEMBL
Affinity DataKi: 4.10E+4nMAssay Description:Irreversible inhibition of Clostridium botulinum BoNT/A light chain expressed in Escherichia coli BL21 (DE3) using SNAPtide as substrate preincubated...More data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Boston University School Of Medicine
Curated by ChEMBL
Boston University School Of Medicine
Curated by ChEMBL
Affinity DataKi: 4.80E+4nMAssay Description:Time dependent inhibition of Clostridium botulinum BoNT/A light chain expressed in Escherichia coli BL21 (DE3) using SNAPtide flp6 as substrate by me...More data for this Ligand-Target Pair
Affinity DataKi: 4.80E+4nMAssay Description:Inhibition of human carbonic anhydrase using p-nitrophenylacetate as substrate preincubated for 10 mins before substrate addition by spectrophotometr...More data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Boston University School Of Medicine
Curated by ChEMBL
Boston University School Of Medicine
Curated by ChEMBL
Affinity DataKi: 5.20E+4nMAssay Description:Covalent inhibition of Clostridium botulinum BoNT/A light chain expressed in Escherichia coli BL21 (DE3) using SNAPtide flp6 as substrate preincubate...More data for this Ligand-Target Pair
Affinity DataKi: 6.40E+4nMAssay Description:Inhibition of human carbonic anhydrase using p-nitrophenylacetate as substrate preincubated for 10 mins before substrate addition by spectrophotometr...More data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Boston University School Of Medicine
Curated by ChEMBL
Boston University School Of Medicine
Curated by ChEMBL
Affinity DataKi: 6.60E+4nMAssay Description:Irreversible inhibition of Clostridium botulinum BoNT/A light chain expressed in Escherichia coli BL21 (DE3) using SNAPtide as substrate preincubated...More data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Boston University School Of Medicine
Curated by ChEMBL
Boston University School Of Medicine
Curated by ChEMBL
Affinity DataKi: 8.80E+4nMAssay Description:Irreversible inhibition of Clostridium botulinum BoNT/A light chain expressed in Escherichia coli BL21 (DE3) using SNAPtide as substrate preincubated...More data for this Ligand-Target Pair
TargetBotulinum neurotoxin type A(Clostridium botulinum)
Boston University School Of Medicine
Curated by ChEMBL
Boston University School Of Medicine
Curated by ChEMBL
Affinity DataKi: 8.80E+4nMAssay Description:Irreversible inhibition of Clostridium botulinum BoNT/A light chain expressed in Escherichia coli BL21 (DE3) using SNAPtide flp6 as substrate preincu...More data for this Ligand-Target Pair
Affinity DataKi: 9.36E+4nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
Affinity DataKi: 2.60E+5nMAssay Description:Inhibition of human carbonic anhydrase using p-nitrophenylacetate as substrate preincubated for 10 mins before substrate addition by spectrophotometr...More data for this Ligand-Target Pair
Affinity DataKi: 2.70E+5nMAssay Description:Inhibition of human carbonic anhydrase using p-nitrophenylacetate as substrate preincubated for 10 mins before substrate addition by spectrophotometr...More data for this Ligand-Target Pair
Affinity DataKi: 4.00E+5nMAssay Description:Compound was evaluated for reversible inhibition of hydrolysis acetylcholine by acetylcholinesterase and represented as KI(noncompetitive)More data for this Ligand-Target Pair
Affinity DataKi: 4.00E+5nMAssay Description:Compound was evaluated for reversible inhibition of hydrolysis acetylcholine by acetylcholinesterase and represented as KI(competitive)More data for this Ligand-Target Pair
Affinity DataKi: 5.10E+5nMAssay Description:Inhibition of human carbonic anhydrase using p-nitrophenylacetate as substrate preincubated for 10 mins before substrate addition by spectrophotometr...More data for this Ligand-Target Pair
Affinity DataKi: 9.50E+5nMAssay Description:Inhibition of human carbonic anhydrase using p-nitrophenylacetate as substrate preincubated for 10 mins before substrate addition by spectrophotometr...More data for this Ligand-Target Pair
Affinity DataKi: 9.50E+5nMAssay Description:Inhibition of human carbonic anhydrase using p-nitrophenylacetate as substrate preincubated for 10 mins before substrate addition by spectrophotometr...More data for this Ligand-Target Pair