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Found 467 with Last Name = 'coric' and Initial = 'p'
TargetNeprilysin(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50407297(CHEMBL2052008)
Affinity DataKi:  0.700nMAssay Description:In vivo inhibitory potency against neutral endopeptidase by displacement of [3H]-HACBOGly binding in mouse kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21653((2S)-2-[(2R)-2-[(1R)-2,3-dihydro-1H-inden-1-yl]-3-...)
Affinity DataKi:  0.700nM ΔG°:  -54.4kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50407297(CHEMBL2052008)
Affinity DataKi:  0.700nMAssay Description:In vivo inhibitory potency against neutral endopeptidase by displacement of [3H]-HACBOGly binding in mouse kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase B(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50036831(6-Amino-2-mercapto-hexanoic acid | CHEMBL432852)
Affinity DataKi:  0.900nMAssay Description:Inhibition of arginylaminopeptidase (aminopeptidase B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM50087104(C-{[3-Biphenyl-4-yl-2-(carboxymethyl-carbamoyl)-pr...)
Affinity DataKi:  0.940nMAssay Description:Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM50087106((2S)-2-[(2S)-3-{[(1S)-1-azaniumylethyl](hydroxy)ph...)
Affinity DataKi:  1.20nMAssay Description:Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM50087088((2S)-2-[(2S)-3-[(1-azaniumylethyl)(hydroxy)phospho...)
Affinity DataKi:  1.40nMAssay Description:Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21649((2S)-3-(1H-indol-3-yl)-2-[(2R,3R)-3-(4-phenylpheny...)
Affinity DataKi:  1.5nM ΔG°:  -52.4kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087089((2S)-2-[(2S)-3-{[(1S)-1-azaniumyl-2-phenylethyl](h...)
Affinity DataKi:  1.5nMAssay Description:Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50407299(CHEMBL2052007)
Affinity DataKi:  1.60nMAssay Description:In vivo inhibitory potency against neutral endopeptidase by displacement of [3H]-HACBOGly binding in mouse kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50407299(CHEMBL2052007)
Affinity DataKi:  1.60nMAssay Description:In vivo inhibitory potency against neutral endopeptidase by displacement of [3H]-HACBOGly binding in mouse kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21639((2S)-2-[2-(2,3-dihydro-1H-inden-1-yl)-3-sulfanylpr...)
Affinity DataKi:  1.80nM ΔG°:  -51.9kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087095(1-{[3-(4-Bromo-phenyl)-2-(1-carboxy-ethylcarbamoyl...)
Affinity DataKi:  1.90nMAssay Description:Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Mus musculus)
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50407299(CHEMBL2052007)
Affinity DataKi:  1.90nMAssay Description:Inhibitory potency against angiotensin converting enzyme by displacement of [3H]-trandolaprilate binding in mouse lungMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Mus musculus)
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50407299(CHEMBL2052007)
Affinity DataKi:  1.90nMAssay Description:Inhibitory potency against angiotensin converting enzyme by displacement of [3H]-trandolaprilate binding in mouse lungMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Rattus norvegicus)
Cnrs

LigandPNGBDBM21642((2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolid...)
Affinity DataKi:  2nMAssay Description:Specific activity of ACE was assayed in black 96-well microplates with or without various concentrations of inhibitors. N-Cbz-Phe-His-Leu was added, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM50087113((2S)-2-[(2S)-3-{[(S)-azaniumyl(phenyl)methyl](hydr...)
Affinity DataKi:  2nMAssay Description:Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21654((2S)-2-[(2S)-2-[(1R)-2,3-dihydro-1H-inden-1-yl]-3-...)
Affinity DataKi:  2.10nM ΔG°:  -51.5kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM50087085((2S)-2-[(2S)-3-{[(1S)-1-azaniumyl-2-phenylethyl](h...)
Affinity DataKi:  2.20nMAssay Description:Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21643(CGS-31,447 | [3-(naphthalen-1-yl)-1-{[(1S)-2-(4-ph...)
Affinity DataKi:  2.20nM ΔG°:  -51.4kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21644((2S)-3-(1H-indol-3-yl)-2-[(2S,3S)-3-phenyl-2-(sulf...)
Affinity DataKi:  2.20nM ΔG°:  -51.4kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087097(1-{[2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-3-phenyl...)
Affinity DataKi:  2.20nMAssay Description:Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM50087085((2S)-2-[(2S)-3-{[(1S)-1-azaniumyl-2-phenylethyl](h...)
Affinity DataKi:  2.30nMAssay Description:Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087084(1-{[2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-3-phenyl...)
Affinity DataKi:  2.30nMAssay Description:Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087093(1-{[2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-3-phenyl...)
Affinity DataKi:  2.30nMAssay Description:Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087094((R,S,S)1-{[2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-4...)
Affinity DataKi:  2.30nMAssay Description:Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21645((2S)-3-(1H-indol-3-yl)-2-[(2R,3R)-3-phenyl-2-(sulf...)
Affinity DataKi:  2.40nM ΔG°:  -51.2kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21646((2S)-3-(1H-indol-3-yl)-2-[(2S,3R)-3-phenyl-2-(sulf...)
Affinity DataKi:  2.5nM ΔG°:  -51.1kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM50087100((2S)-2-[(2S)-3-{[azaniumyl(phenyl)methyl](hydroxy)...)
Affinity DataKi:  2.90nMAssay Description:Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087106((2S)-2-[(2S)-3-{[(1S)-1-azaniumylethyl](hydroxy)ph...)
Affinity DataKi:  2.90nMAssay Description:Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087089((2S)-2-[(2S)-3-{[(1S)-1-azaniumyl-2-phenylethyl](h...)
Affinity DataKi:  2.90nMAssay Description:Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21635((2S)-3-(1H-indol-3-yl)-2-[3-phenyl-2-(sulfanylmeth...)
Affinity DataKi:  3nM ΔG°:  -50.6kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21657((2S)-3-(1H-indol-3-yl)-2-[(2R)-3-sulfanyl-2-[(1R)-...)
Affinity DataKi:  3nM ΔG°:  -50.6kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21658((2S)-3-(1H-indol-3-yl)-2-[(2S)-3-sulfanyl-2-[(1R)-...)
Affinity DataKi:  3nM ΔG°:  -50.6kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087114(C-{[2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-3-phenyl...)
Affinity DataKi:  3.10nMAssay Description:Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087096(1-{[2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-3-phenyl...)
Affinity DataKi:  3.20nMAssay Description:Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM50087101(1-{[3-Biphenyl-4-yl-2-(1-carboxy-propylcarbamoyl)-...)
Affinity DataKi:  3.30nMAssay Description:Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087105(1-{[3-Biphenyl-4-yl-2-(1-carboxy-2-phenyl-ethylcar...)
Affinity DataKi:  3.70nMAssay Description:Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21641(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)
Affinity DataKi:  4nM ΔG°:  -49.9kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087111((2S)-2-[(2S)-3-{[(S)-azaniumyl(phenyl)methyl](hydr...)
Affinity DataKi:  4.20nMAssay Description:Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087098((2S)-2-[(2S)-3-{[azaniumyl(phenyl)methyl](hydroxy)...)
Affinity DataKi:  4.20nMAssay Description:Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21640((2S)-3-(1H-indol-3-yl)-2-[3-sulfanyl-2-(1,2,3,4-te...)
Affinity DataKi:  4.5nM ΔG°:  -49.6kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087094((R,S,S)1-{[2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-4...)
Affinity DataKi:  4.60nMAssay Description:Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087113((2S)-2-[(2S)-3-{[(S)-azaniumyl(phenyl)methyl](hydr...)
Affinity DataKi:  4.80nMAssay Description:Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21636((2S)-3-(1H-indol-3-yl)-2-[3-(4-phenylphenyl)-2-(su...)
Affinity DataKi:  4.80nM ΔG°:  -49.4kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM50087095(1-{[3-(4-Bromo-phenyl)-2-(1-carboxy-ethylcarbamoyl...)
Affinity DataKi:  4.90nMAssay Description:Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087119(C-{[3-Biphenyl-4-yl-2-(1-carboxy-2-hydroxy-ethylca...)
Affinity DataKi:  4.90nMAssay Description:Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21651((2S)-3-(1H-indol-3-yl)-2-[(2R,3S)-3-(4-phenylpheny...)
Affinity DataKi:  5nM ΔG°:  -49.3kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21647((2S)-3-(1H-indol-3-yl)-2-[(2R,3S)-3-phenyl-2-(sulf...)
Affinity DataKi:  5nM ΔG°:  -49.3kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087088((2S)-2-[(2S)-3-[(1-azaniumylethyl)(hydroxy)phospho...)
Affinity DataKi:  5.20nMAssay Description:Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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