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Found 533 with Last Name = 'fridman' and Initial = 'js'
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50300312(4-amino-1,2,5-oxadiazole-3-carboximidamide | CHEMB...)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of N-terminal his-tagged human indoleamine 2,3-dioxygenase expressed in Escherichia coli assessed as N'-formylkynurenine formation by spec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50300305(4-Amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2...)
Affinity DataKi:  3.40E+4nMAssay Description:Competitive inhibition of IDO1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM11868(CHEMBL256157 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataIC50: <1.5nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM11868(CHEMBL256157 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataIC50: <1.5nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM11868(CHEMBL256157 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataIC50: <1.5nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50229639((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)
Affinity DataIC50:  4nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50203526((6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carb...)
Affinity DataIC50:  5nMAssay Description:Binding affinity to MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50203526((6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carb...)
Affinity DataIC50:  5nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50228003((6S,7S)-6-[4-(4-cyano-3-methyl-phenyl)-piperazine-...)
Affinity DataIC50: <5nMAssay Description:Binding affinity to MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229655(CHEMBL442432 | trans-2-hydroxycyclopentyl 4-(hydro...)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229651((S)-pyrrolidin-2-ylmethyl 4-((4-(4-cyano-2-methylp...)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229639((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)
Affinity DataIC50:  7.10nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50126143(Epacadostat | INCB-024360)
Affinity DataIC50:  7.40nMAssay Description:Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrsMore data for this Ligand-Target Pair
LigandPNGBDBM50229641(CHEMBL400528 | pyrrolidin-3-yl 4-((4-(4-cyano-2-me...)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50268906((2S,3S,5RS)-N-hydroxy-5-(2-oxo-2-(pyrrolidin-1-yl)...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50229634((S)-tetrahydrofuran-3-yl 4-((4-(4-cyanophenyl)pipe...)
Affinity DataIC50:  9nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229651((S)-pyrrolidin-2-ylmethyl 4-((4-(4-cyano-2-methylp...)
Affinity DataIC50:  9.10nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50300306(4-Amino-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,...)
Affinity DataIC50:  10nMAssay Description:Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229639((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)
Affinity DataIC50:  10nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50233431(CHEMBL3979473 | US9789094, 5)
Affinity DataIC50:  11nMAssay Description:Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229660(3-methyl-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)...)
Affinity DataIC50:  11nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229636((R)-pyrrolidin-2-ylmethyl 4-((4-(4-cyano-2-methylp...)
Affinity DataIC50:  11nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50300306(4-Amino-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,...)
Affinity DataIC50:  12nMAssay Description:Inhibition of indoleamine 2,3-dioxygenase in IFN-gamma-stimulated human HeLa cells assessed as kynurenine formation by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229643((S)-tetrahydrofuran-3-yl 4-((4-(4-cyano-2-methylph...)
Affinity DataIC50:  12nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229657((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)
Affinity DataIC50:  13nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50203538((6S,7S)-6-(3-phenyl-2,5-dihydro-pyrrole-1-carbonyl...)
Affinity DataIC50:  13nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50203538((6S,7S)-6-(3-phenyl-2,5-dihydro-pyrrole-1-carbonyl...)
Affinity DataIC50:  13nMAssay Description:Binding affinity to MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50228006((6S,7S)-6-(4-m-tolyl-3,6-dihydro-2H-pyridine-1-car...)
Affinity DataIC50:  13nMAssay Description:Binding affinity to MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229641(CHEMBL400528 | pyrrolidin-3-yl 4-((4-(4-cyano-2-me...)
Affinity DataIC50:  13nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50203538((6S,7S)-6-(3-phenyl-2,5-dihydro-pyrrole-1-carbonyl...)
Affinity DataIC50:  13nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50203538((6S,7S)-6-(3-phenyl-2,5-dihydro-pyrrole-1-carbonyl...)
Affinity DataIC50:  13nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50229657((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)
Affinity DataIC50:  13nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50233424(CHEMBL4076756)
Affinity DataIC50:  14nMAssay Description:Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50227991((6S,7S)-6-[4-(3,5-difluoro-phenyl)-3,6-dihydro-2H-...)
Affinity DataIC50:  14nMAssay Description:Binding affinity to MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229635(4,4-dimethyl-tetrahydrofuran-3-yl 4-(hydroxycarbam...)
Affinity DataIC50:  14nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50228004((6S,7S)-6-[4-(3-chloro-phenyl)-piperazine-1-carbon...)
Affinity DataIC50:  14nMAssay Description:Binding affinity to ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229643((S)-tetrahydrofuran-3-yl 4-((4-(4-cyano-2-methylph...)
Affinity DataIC50:  14nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50269057((1S,2S,5S)-N-hydroxy-5-(2-oxo-2-(piperidin-1-yl)et...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human recombinant ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229657((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)
Affinity DataIC50:  15nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227991((6S,7S)-6-[4-(3,5-difluoro-phenyl)-3,6-dihydro-2H-...)
Affinity DataIC50:  15nMAssay Description:Binding affinity to ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50233430(CHEMBL3955791 | US11207302, Example 2)
Affinity DataIC50:  16nMAssay Description:Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229656(CHEMBL252612 | pyrrolidin-3-yl 4-(hydroxycarbamoyl...)
Affinity DataIC50:  16nMAssay Description:Inhibition of HER2 sheddase in human BT474 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227997((6S,7S)-6-[4-(3-isopropyl-phenyl)-piperidine-1-car...)
Affinity DataIC50:  16nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229655(CHEMBL442432 | trans-2-hydroxycyclopentyl 4-(hydro...)
Affinity DataIC50:  16nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50300299(4-Amino-N-(3-bromophenyl)-N'-hydroxy-1,2,5-oxadiaz...)
Affinity DataIC50:  17nMAssay Description:Inhibition of indoleamine 2,3-dioxygenase in IFN-gamma-stimulated human HeLa cells assessed as kynurenine formation by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50233429(CHEMBL4083203)
Affinity DataIC50:  17nMAssay Description:Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229650((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)
Affinity DataIC50:  18nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50269057((1S,2S,5S)-N-hydroxy-5-(2-oxo-2-(piperidin-1-yl)et...)
Affinity DataIC50:  18nMAssay Description:Inhibition of HER2 extracellular domain sheddase activity in human BT474 cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50203526((6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carb...)
Affinity DataIC50:  18nMAssay Description:Inhibition of HER2 sheddase in BT474 cells by extracellular domain shedding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50229640((S)-tetrahydrofuran-3-yl 4-(hydroxycarbamoyl)-4-((...)
Affinity DataIC50:  18nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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