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Found 40 with Last Name = 'fukumura' and Initial = 't'
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
National Institute Of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50163592((3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-(4-met...)
Affinity DataKi:  0.340nMAssay Description:Binding affinity to mGluR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
National Institute Of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50301822(5-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-tria...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to mGluR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
National Institute Of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50301822(5-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-tria...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to mGluR1 by PET analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50266889(CHEMBL513922 | N-benzyl-N-ethyl-2-(7-methyl-8-oxo-...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [11C]-PK-11195 from TPSO in Sprague-Dawley rat brain homogenate after 30 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50054139((R)1-(2-Chloro-phenyl)-isoquinoline-3-carboxylic a...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [11C]-PK-11195 from TPSO in Sprague-Dawley rat brain homogenate after 30 mins by gamma countingMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
National Institute Of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50333368(CHEMBL1645348 | [11C]-cis-(3-ethyl-2-methylquinoli...)
Affinity DataKi:  0.870nMAssay Description:Binding affinity to mGluR1 by PET analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
National Institute Of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50333368(CHEMBL1645348 | [11C]-cis-(3-ethyl-2-methylquinoli...)
Affinity DataKi:  0.870nMAssay Description:Binding affinity to mGluR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50440024(CHEMBL2425785)
Affinity DataKi:  1nMAssay Description:Displacement of [125I]-orexin-A from human OX2 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50440024(CHEMBL2425785)
Affinity DataKi:  1nMAssay Description:Displacement of [125I]-orexin-A from human OX1 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50440021(CHEMBL2425788)
Affinity DataKi:  1nMAssay Description:Displacement of [125I]-orexin-A from human OX2 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50440022(CHEMBL2425787)
Affinity DataKi:  2nMAssay Description:Displacement of [125I]-orexin-A from human OX2 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50440025(CHEMBL2425784)
Affinity DataKi:  2nMAssay Description:Displacement of [125I]-orexin-A from human OX2 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
National Institute Of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50273942(4-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-tria...)
Affinity DataKi:  2nMAssay Description:Binding affinity to mGluR1 by PET analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50440025(CHEMBL2425784)
Affinity DataKi:  3nMAssay Description:Displacement of [125I]-orexin-A from human OX1 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
National Institute Of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50273942(4-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-tria...)
Affinity DataKi:  3.90nMAssay Description:Binding affinity to mGluR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
National Institute Of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50333371(CHEMBL1645351 | CHEMBL1771388 | [11C]-6-N-cyclohex...)
Affinity DataKi:  4.80nMAssay Description:Binding affinity to mGluR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
National Institute Of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50333371(CHEMBL1645351 | CHEMBL1771388 | [11C]-6-N-cyclohex...)
Affinity DataKi:  4.80nMAssay Description:Binding affinity to mGluR1 by PET analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50440023(CHEMBL2425786)
Affinity DataKi:  5nMAssay Description:Displacement of [125I]-orexin-A from human OX2 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50401000(CHEMBL2206282)
Affinity DataKi:  5.10nMAssay Description:Displacement of [11C]-PK-11195 from TPSO in Sprague-Dawley rat brain homogenate after 30 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
National Institute Of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50301520(4-fluoro-N-(4-(6-(isopropylamino)pyrimidin-4-yl)th...)
Affinity DataKi:  5.40nMAssay Description:Displacement of 4-[18F]fluoro-N-[4-(6-(isopropylamino)pyrimidin-4-yl)-1,3-thiazol-2-yl]-N-methylbenzamide from mGluR1 in Sprague-Dawley rat brain hom...More data for this Ligand-Target Pair
TargetOrexin receptor type 2(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50440026(CHEMBL2425783)
Affinity DataKi:  7nMAssay Description:Displacement of [125I]-orexin-A from human OX2 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50440021(CHEMBL2425788)
Affinity DataKi:  9nMAssay Description:Displacement of [125I]-orexin-A from human OX1 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50440022(CHEMBL2425787)
Affinity DataKi:  12nMAssay Description:Displacement of [125I]-orexin-A from human OX1 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
National Institute Of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50388957(CHEMBL2063722)
Affinity DataKi:  12.6nMAssay Description:Displacement of 4-[18F]fluoro-N-[4-(6-(isopropylamino)pyrimidin-4-yl)-1,3-thiazol-2-yl]-N-methylbenzamide from mGluR1 in Sprague-Dawley rat brain hom...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50400999(CHEMBL2206283)
Affinity DataKi:  13.2nMAssay Description:Displacement of [11C]-PK-11195 from TPSO in Sprague-Dawley rat brain homogenate after 30 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50440026(CHEMBL2425783)
Affinity DataKi:  30nMAssay Description:Displacement of [125I]-orexin-A from human OX1 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50440023(CHEMBL2425786)
Affinity DataKi:  32nMAssay Description:Displacement of [125I]-orexin-A from human OX1 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
National Institute Of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50400998(CHEMBL2206284)
Affinity DataKi:  40nMAssay Description:Displacement of [11C]-PK-11195 from TPSO in Sprague-Dawley rat brain homogenate after 30 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
National Institute Of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50388958(CHEMBL2063723)
Affinity DataKi:  153nMAssay Description:Displacement of 4-[18F]fluoro-N-[4-(6-(isopropylamino)pyrimidin-4-yl)-1,3-thiazol-2-yl]-N-methylbenzamide from mGluR1 in Sprague-Dawley rat brain hom...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
National Institute Of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50388959(CHEMBL2063724)
Affinity DataKi: >5.00E+3nMAssay Description:Displacement of 4-[18F]fluoro-N-[4-(6-(isopropylamino)pyrimidin-4-yl)-1,3-thiazol-2-yl]-N-methylbenzamide from mGluR1 in Sprague-Dawley rat brain hom...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Mus musculus)
National Institute Of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50333367(6-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-tria...)
Affinity DataIC50:  1.40nMAssay Description:Binding affinity to mouse mGluR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
National Institute Of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50333367(6-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-tria...)
Affinity DataIC50:  3.60nMAssay Description:Binding affinity to human mGluR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
National Institute Of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50301520(4-fluoro-N-(4-(6-(isopropylamino)pyrimidin-4-yl)th...)
Affinity DataIC50:  13.9nMAssay Description:Displacement of 4-[18F]fluoro-N-[4-(6-(isopropylamino)pyrimidin-4-yl)-1,3-thiazol-2-yl]-N-methylbenzamide from mGluR1 in Sprague-Dawley rat brain hom...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 1(RAT)
National Institute Of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50388957(CHEMBL2063722)
Affinity DataIC50:  32.7nMAssay Description:Displacement of 4-[18F]fluoro-N-[4-(6-(isopropylamino)pyrimidin-4-yl)-1,3-thiazol-2-yl]-N-methylbenzamide from mGluR1 in Sprague-Dawley rat brain hom...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
National Institute Of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50388958(CHEMBL2063723)
Affinity DataIC50:  395nMAssay Description:Displacement of 4-[18F]fluoro-N-[4-(6-(isopropylamino)pyrimidin-4-yl)-1,3-thiazol-2-yl]-N-methylbenzamide from mGluR1 in Sprague-Dawley rat brain hom...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute Of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50388958(CHEMBL2063723)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [11C]-ABP688 from mGluR5 in Sprague-Dawley rat brain homogenates after 1 hr by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute Of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50388957(CHEMBL2063722)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [11C]-ABP688 from mGluR5 in Sprague-Dawley rat brain homogenates after 1 hr by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute Of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50301520(4-fluoro-N-(4-(6-(isopropylamino)pyrimidin-4-yl)th...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [11C]-ABP688 from mGluR5 in Sprague-Dawley rat brain homogenates after 1 hr by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
National Institute Of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50388959(CHEMBL2063724)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of 4-[18F]fluoro-N-[4-(6-(isopropylamino)pyrimidin-4-yl)-1,3-thiazol-2-yl]-N-methylbenzamide from mGluR1 in Sprague-Dawley rat brain hom...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
National Institute Of Radiological Sciences

Curated by ChEMBL
LigandPNGBDBM50388959(CHEMBL2063724)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [11C]-ABP688 from mGluR5 in Sprague-Dawley rat brain homogenates after 1 hr by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed