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Found 30 with Last Name = 'galicia' and Initial = 't'
LigandPNGBDBM14423(4-{[3-(3-ethoxyphenyl)-1-methyl-2-oxo-2,3-dihydro-...)
Affinity DataIC50:  0.5nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14434(6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl...)
Affinity DataIC50:  0.650nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
LigandPNGBDBM14419(4-{[3-(3-chlorophenyl)-1-methyl-2-oxo-2,3-dihydro-...)
Affinity DataIC50:  1.40nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14421(4-{hydroxy[3-(3-methoxyphenyl)-1-methyl-2-oxo-2,3-...)
Affinity DataIC50:  5.10nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14429(4-({3-[(3-chlorophenyl)methyl]-1-methyl-2-oxo-2,3-...)
Affinity DataIC50:  5.20nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14422(5-[(4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-...)
Affinity DataIC50:  6.60nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14420(5-[(4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-...)
Affinity DataIC50:  6.70nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14425(4-{[3-(2H-1,3-benzodioxol-5-yl)-1-methyl-2-oxo-2,3...)
Affinity DataIC50:  8nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14433(4-[2-(4-{6,15-dibromo-13-chloro-4-azatricyclo[9.4....)
Affinity DataIC50:  8.30nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
LigandPNGBDBM14417(3-(3-chlorophenyl)-5-[(4-chlorophenyl)(hydroxy)(1-...)
Affinity DataIC50:  16nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14426(5-[(4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-...)
Affinity DataIC50:  21nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14418(3-(3-chlorophenyl)-5-[hydroxy(4-iodophenyl)(1-meth...)
Affinity DataIC50:  24nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14430((4-chlorophenyl)[1-(3-chlorophenyl)-1H-indol-6-yl]...)
Affinity DataIC50:  36nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14428(3-[(3-chlorophenyl)methyl]-5-[hydroxy(4-iodophenyl...)
Affinity DataIC50:  71nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14427(5-[(4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-...)
Affinity DataIC50:  150nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14424(3-(2H-1,3-benzodioxol-5-yl)-5-[(4-chlorophenyl)(hy...)
Affinity DataIC50:  150nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14431((4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)[1-(nap...)
Affinity DataIC50:  200nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14434(6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl...)
Affinity DataIC50:  1.10E+3nMAssay Description:The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...More data for this Ligand-Target Pair
LigandPNGBDBM14432(1-(3-chlorophenyl)-5-[(4-chlorophenyl)(hydroxy)(1-...)
Affinity DataIC50:  1.10E+3nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14418(3-(3-chlorophenyl)-5-[hydroxy(4-iodophenyl)(1-meth...)
Affinity DataIC50:  1.20E+3nMAssay Description:The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14419(4-{[3-(3-chlorophenyl)-1-methyl-2-oxo-2,3-dihydro-...)
Affinity DataIC50:  1.80E+3nMAssay Description:The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14426(5-[(4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-...)
Affinity DataIC50:  2.90E+3nMAssay Description:The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14429(4-({3-[(3-chlorophenyl)methyl]-1-methyl-2-oxo-2,3-...)
Affinity DataIC50:  5.60E+3nMAssay Description:The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14422(5-[(4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-...)
Affinity DataIC50:  7.50E+3nMAssay Description:The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14423(4-{[3-(3-ethoxyphenyl)-1-methyl-2-oxo-2,3-dihydro-...)
Affinity DataIC50: >1.00E+4nMAssay Description:The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14425(4-{[3-(2H-1,3-benzodioxol-5-yl)-1-methyl-2-oxo-2,3...)
Affinity DataIC50: >1.00E+4nMAssay Description:The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14420(5-[(4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-...)
Affinity DataIC50: >1.00E+4nMAssay Description:The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14433(4-[2-(4-{6,15-dibromo-13-chloro-4-azatricyclo[9.4....)
Affinity DataIC50: >1.00E+4nMAssay Description:The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...More data for this Ligand-Target Pair
LigandPNGBDBM14421(4-{hydroxy[3-(3-methoxyphenyl)-1-methyl-2-oxo-2,3-...)
Affinity DataIC50: >1.00E+4nMAssay Description:The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14417(3-(3-chlorophenyl)-5-[(4-chlorophenyl)(hydroxy)(1-...)
Affinity DataIC50:  1.10E+4nMAssay Description:The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed