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Found 194 with Last Name = 'haberthuer' and Initial = 's'
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM25771(1-hydroxy-2-naphthoic acid;4-[1-hydroxy-2-[6-(4-ph...)
Affinity DataKi:  1nMAssay Description:Binding affinity for human beta-2 adrenergic receptorMore data for this Ligand-Target Pair
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM86453(CAS_73573-87-2 | Formoterol | NSC_3083544)
Affinity DataKi:  2.60nMAssay Description:Binding affinity for human beta-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50151724(CHEMBL183948 | N-[2-Hydroxy-5-(1-hydroxy-2-{2-[3-(...)
Affinity DataKi:  3.30nMAssay Description:Binding affinity for human beta-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50151719(CHEMBL363329 | N-[2-Hydroxy-5-(1-hydroxy-2-{2-[4-(...)
Affinity DataKi:  5.90nMAssay Description:Binding affinity for human beta-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50151721(CHEMBL363260 | N-(2-Hydroxy-5-{(R)-1-hydroxy-2-[2-...)
Affinity DataKi:  7.80nMAssay Description:Binding affinity for human beta-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50151718(CHEMBL440561 | N-[2-Hydroxy-5-((R)-1-hydroxy-2-{2-...)
Affinity DataKi:  8.5nMAssay Description:Binding affinity for human beta-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50151723(CHEMBL185052 | N-[2-Hydroxy-5-((R)-1-hydroxy-2-{2-...)
Affinity DataKi:  9.20nMAssay Description:Binding affinity for human beta-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166735(3-[5-(2-Methyl-imidazol-1-yl)-2-(pyrazin-2-ylamino...)
Affinity DataKi:  10nMAssay Description:Inhibition of luciferase production elicited by NECA by compound in CHO cells transfected with human adenosine A2b receptor and a luciferase expressi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50151717(CHEMBL184538 | N-[2-Hydroxy-5-(1-hydroxy-2-{2-[4-(...)
Affinity DataKi:  12nMAssay Description:Binding affinity for human beta-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166742(3-[2-(3-Methyl-pyridin-2-ylamino)-5-[1,2,4]triazol...)
Affinity DataKi:  20nMAssay Description:Inhibition of luciferase production elicited by NECA by compound in CHO cells transfected with human adenosine A2b receptor and a luciferase expressi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166739(3-[2-(Pyridin-2-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  24nMAssay Description:Displacement of [125I]-AB-MECA from human adenosine A3 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50151722(CHEMBL185262 | N-(2-Hydroxy-5-{1-hydroxy-2-[2-(4-p...)
Affinity DataKi:  35nMAssay Description:Binding affinity for human beta-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166742(3-[2-(3-Methyl-pyridin-2-ylamino)-5-[1,2,4]triazol...)
Affinity DataKi:  37nMAssay Description:Displacement of [125I]-AB-MECA from human adenosine A3 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166739(3-[2-(Pyridin-2-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  53nMAssay Description:Inhibition of luciferase production elicited by NECA by compound in CHO cells transfected with human adenosine A2b receptor and a luciferase expressi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166745(3-[2-(Pyridin-4-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  62nMAssay Description:Inhibition of luciferase production elicited by NECA by compound in CHO cells transfected with human adenosine A2b receptor and a luciferase expressi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166737(3-[2-(Pyridin-3-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  86nMAssay Description:Inhibition of luciferase production elicited by NECA by compound in CHO cells transfected with human adenosine A2b receptor and a luciferase expressi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166743(3-[5-Imidazol-1-yl-2-(pyridin-3-ylamino)-thiazol-4...)
Affinity DataKi:  92nMAssay Description:Inhibition of luciferase production elicited by NECA by compound in CHO cells transfected with human adenosine A2b receptor and a luciferase expressi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166743(3-[5-Imidazol-1-yl-2-(pyridin-3-ylamino)-thiazol-4...)
Affinity DataKi:  124nMAssay Description:Displacement of [125I]-AB-MECA from human adenosine A3 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166741(4-(3-cyanophenyl)-5-(1H-1,2,4-triazol-1-yl)-1,3-th...)
Affinity DataKi:  134nMAssay Description:Displacement of [125I]-AB-MECA from human adenosine A3 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166735(3-[5-(2-Methyl-imidazol-1-yl)-2-(pyrazin-2-ylamino...)
Affinity DataKi:  175nMAssay Description:Displacement of [3H]ZM-241,385 from human adenosine A2a receptors transfected in HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166735(3-[5-(2-Methyl-imidazol-1-yl)-2-(pyrazin-2-ylamino...)
Affinity DataKi:  224nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166745(3-[2-(Pyridin-4-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  304nMAssay Description:Displacement of [125I]-AB-MECA from human adenosine A3 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166741(4-(3-cyanophenyl)-5-(1H-1,2,4-triazol-1-yl)-1,3-th...)
Affinity DataKi:  365nMAssay Description:Inhibition of luciferase production elicited by NECA by compound in CHO cells transfected with human adenosine A2b receptor and a luciferase expressi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166735(3-[5-(2-Methyl-imidazol-1-yl)-2-(pyrazin-2-ylamino...)
Affinity DataKi:  419nMAssay Description:Displacement of [125I]-AB-MECA from human adenosine A3 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166743(3-[5-Imidazol-1-yl-2-(pyridin-3-ylamino)-thiazol-4...)
Affinity DataKi:  560nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166737(3-[2-(Pyridin-3-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  698nMAssay Description:Displacement of [125I]-AB-MECA from human adenosine A3 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166737(3-[2-(Pyridin-3-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  1.53E+3nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166739(3-[2-(Pyridin-2-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  1.76E+3nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166739(3-[2-(Pyridin-2-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  2.02E+3nMAssay Description:Displacement of [3H]ZM-241,385 from human adenosine A2a receptors transfected in HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207120(3-isobutyl-8-((6-methoxyisoquinolin-4-yl)methyl)-1...)
Affinity DataKi:  2.30E+3nMAssay Description:Inhibition of adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166737(3-[2-(Pyridin-3-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  2.57E+3nMAssay Description:Displacement of [3H]ZM-241,385 from human adenosine A2a receptors transfected in HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166743(3-[5-Imidazol-1-yl-2-(pyridin-3-ylamino)-thiazol-4...)
Affinity DataKi:  2.70E+3nMAssay Description:Displacement of [3H]ZM-241,385 from human adenosine A2a receptors transfected in HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166741(4-(3-cyanophenyl)-5-(1H-1,2,4-triazol-1-yl)-1,3-th...)
Affinity DataKi:  2.84E+3nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166745(3-[2-(Pyridin-4-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  3.78E+3nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166745(3-[2-(Pyridin-4-ylamino)-5-[1,2,4]triazol-1-yl-thi...)
Affinity DataKi:  4.16E+3nMAssay Description:Displacement of [3H]ZM-241,385 from human adenosine A2a receptors transfected in HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166741(4-(3-cyanophenyl)-5-(1H-1,2,4-triazol-1-yl)-1,3-th...)
Affinity DataKi:  5.61E+3nMAssay Description:Displacement of [3H]ZM-241,385 from human adenosine A2a receptors transfected in HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166742(3-[2-(3-Methyl-pyridin-2-ylamino)-5-[1,2,4]triazol...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptors transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166742(3-[2-(3-Methyl-pyridin-2-ylamino)-5-[1,2,4]triazol...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]ZM-241,385 from human adenosine A2a receptors transfected in HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50108504(4-(8-(benzo[c][1,2,5]oxadiazol-5-yl)-1,7-naphthyri...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50108504(4-(8-(benzo[c][1,2,5]oxadiazol-5-yl)-1,7-naphthyri...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207130(8-((6,7-dimethoxy-1-methylisoquinolin-4-yl)methyl)...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207120(3-isobutyl-8-((6-methoxyisoquinolin-4-yl)methyl)-1...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50117734(8-{5-[4-(2-Hydroxy-ethyl)-piperidine-1-sulfonyl]-2...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50113973(CHEMBL3605513)
Affinity DataIC50:  3nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP04972/P11541/P16586/P22571/P23439/Q95142(Bos taurus)
Novartis Horsham Research Centre

Curated by ChEMBL
LigandPNGBDBM50117721(3-Isobutyl-1-methyl-8-[5-(piperazin-1-ylmethanesul...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration against bovine retina phosphodiesterase 6 activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50117711(8-{5-[4-(2-Hydroxy-ethyl)-piperazine-1-sulfonyl]-2...)
Affinity DataIC50:  3.5nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50117719(4-[3-(3-Isobutyl-1-methyl-2,6-dioxo-2,3,6,7-tetrah...)
Affinity DataIC50:  3.5nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50117724(3-(3-Isobutyl-1-methyl-2,6-dioxo-2,3,6,7-tetrahydr...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207121(CHEMBL245648 | N-(4-((8-((6,7-dimethoxyisoquinolin...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50117721(3-Isobutyl-1-methyl-8-[5-(piperazin-1-ylmethanesul...)
Affinity DataIC50:  5.5nMAssay Description:Inhibitory activity against human platelet Phosphodiesterase 5 (PDE5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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