Affinity DataKi: 0.300nM Kd: 0.100nMAssay Description:Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay.More data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay.More data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay.More data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Sib Swiss Institute Of Bioinformatics
Curated by ChEMBL
Sib Swiss Institute Of Bioinformatics
Curated by ChEMBL
Affinity DataKi: 94nMAssay Description:Inhibition of human recombinant IDO1 using L-tryptophan as substrate preincubated for 5 mins followed by substrate addition measured after 10 mins by...More data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Sib Swiss Institute Of Bioinformatics
Curated by ChEMBL
Sib Swiss Institute Of Bioinformatics
Curated by ChEMBL
Affinity DataKi: 100nMAssay Description:Noncompetitive inhibition of human recombinant IDO1 expressed in Escherichia coli by Michaelis-Menton nonlinear regression plot analysis in presence ...More data for this Ligand-Target Pair
Affinity DataKi: 320nM Kd: 71nMAssay Description:Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay.More data for this Ligand-Target Pair
Affinity DataKi: 845nM Kd: 167nMAssay Description:Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay.More data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Sib Swiss Institute Of Bioinformatics
Curated by ChEMBL
Sib Swiss Institute Of Bioinformatics
Curated by ChEMBL
Affinity DataKi: 1.50E+3nMAssay Description:Inhibition of human recombinant IDO1 expressed in yeast IS20-2B using tryptophan as substrate by methylene blue/ascorbate assayMore data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Sib Swiss Institute Of Bioinformatics
Curated by ChEMBL
Sib Swiss Institute Of Bioinformatics
Curated by ChEMBL
Affinity DataKi: 4.30E+3nMAssay Description:Inhibition of human recombinant IDO1 using L-tryptophan as substrate after 15 mins by Dixon plot analysisMore data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Sib Swiss Institute Of Bioinformatics
Curated by ChEMBL
Sib Swiss Institute Of Bioinformatics
Curated by ChEMBL
Affinity DataKi: 1.20E+4nMAssay Description:Competitive inhibition of 6His-tagged human recombinant IDO expressed in Escherichia coli BL21DE3pLysMore data for this Ligand-Target Pair
Affinity DataKi: 1.20E+4nMAssay Description:Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay.More data for this Ligand-Target Pair
Affinity DataKi: 2.00E+4nMAssay Description:Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay.More data for this Ligand-Target Pair
Affinity DataKi: 3.80E+4nMAssay Description:Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay.More data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Sib Swiss Institute Of Bioinformatics
Curated by ChEMBL
Sib Swiss Institute Of Bioinformatics
Curated by ChEMBL
Affinity DataKi: 1.60E+5nMAssay Description:Noncompetitive inhibition of human recombinant IDO1 expressed in Escherichia coli BL21 by Lineweaver-Burk double-reciprocal plot analysisMore data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Sib Swiss Institute Of Bioinformatics
Curated by ChEMBL
Sib Swiss Institute Of Bioinformatics
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human IDO1 in HEK293 cells after 20 hrs by plate reader assayMore data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Mus musculus)
Ludwig Center For Cancer Research Of The University Of Lausanne
Curated by ChEMBL
Ludwig Center For Cancer Research Of The University Of Lausanne
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of mouse IDO1 in P815 clone 6 cells by HPLC analysisMore data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
The M.S. University Of Baroda
Curated by ChEMBL
The M.S. University Of Baroda
Curated by ChEMBL
Affinity DataIC50: <2nMAssay Description:Inhibition of wild-type HIV1 reverse transcriptaseMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
The M.S University Of Baroda
Curated by ChEMBL
The M.S University Of Baroda
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human COX-2 expressed in Baculovirus infected sf9 cells using arachidonic acid as substrate preincubated for 10 mins follow...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
The M.S University Of Baroda
Curated by ChEMBL
The M.S University Of Baroda
Curated by ChEMBL
Affinity DataIC50: 2.80nMAssay Description:Inhibition of COX-2 in human whole bloodMore data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Sib Swiss Institute Of Bioinformatics
Curated by ChEMBL
Sib Swiss Institute Of Bioinformatics
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human IDO1 in HEK293 cells after 20 hrs by plate reader assayMore data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Sib Swiss Institute Of Bioinformatics
Curated by ChEMBL
Sib Swiss Institute Of Bioinformatics
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human IDO1 in HEK293 cells after 20 hrs by plate reader assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of house dust mite Derp-1 after 20 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as reduction in symmetrical dimethylation of arginine containing substrate using SmD3 as substrate i...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of COX-1 in LPS-induced mouse peritoneal macrophagesMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
The M.S University Of Baroda
Curated by ChEMBL
The M.S University Of Baroda
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human COX-2 expressed in human COS cells using arachidonic acid as substrateMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
The M.S University Of Baroda
Curated by ChEMBL
The M.S University Of Baroda
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human COX-2 expressed in CHO-K1 cells using arachidonic acid as substrate preincubated for 15 mins followed by substrate ad...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of house dust mite Derp-1 after 20 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of house dust mite Derp-1 after 20 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of house dust mite Derp-1 after 20 minsMore data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Epizyme
Curated by ChEMBL
Epizyme
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of human full length FLAG-tagged PRMT5/human His6-tagged MEP50 expressed in baculovirus-infected Sf9 cells assessed as reduction in tritiu...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of house dust mite Derp-1 after 20 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of house dust mite Derp-1 after 20 minsMore data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Sib Swiss Institute Of Bioinformatics
Curated by ChEMBL
Sib Swiss Institute Of Bioinformatics
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human IDO1 in HEK293 cells after 20 hrs by plate reader assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
The M.S University Of Baroda
Curated by ChEMBL
The M.S University Of Baroda
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of COX-2 in human 143982 cellsMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
The M.S University Of Baroda
Curated by ChEMBL
The M.S University Of Baroda
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human COX-2 expressed in Baculovirus infected sf9 cells using arachidonic acid as substrate preincubated for 10 mins follow...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of house dust mite Derp-1 after 20 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of house dust mite Derp-1 after 20 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of house dust mite Derp-1 after 20 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of house dust mite Derp-1 after 20 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of house dust mite Derp-1 after 20 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 6.30nMAssay Description:The fluorogenic substrate used for measuring Der p 1 proteolytic activity was 2-aminobenzoylvalylalanylnorleucylseryl-(3-nitro)tyrosinyl aspartamide....More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of house dust mite Derp-1 after 20 minsMore data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Sib Swiss Institute Of Bioinformatics
Curated by ChEMBL
Sib Swiss Institute Of Bioinformatics
Curated by ChEMBL
Affinity DataIC50: 7.10nMAssay Description:Inhibition of IFN-gamma-stimulated IDO1 activity in human HeLa cells using L-tryptophan as substrate after 48 hrs by microplate reader analysisMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
The M.S University Of Baroda
Curated by ChEMBL
The M.S University Of Baroda
Curated by ChEMBL
Affinity DataIC50: 7.5nMAssay Description:Inhibition of recombinant human COX-2 expressed in Baculovirus infected sf9 cells using arachidonic acid as substrate preincubated for 10 mins follow...More data for this Ligand-Target Pair
Affinity DataIC50: 7.85nMAssay Description:The fluorogenic substrate used for measuring Der p 1 proteolytic activity was 2-aminobenzoylvalylalanylnorleucylseryl-(3-nitro)tyrosinyl aspartamide....More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of house dust mite Derp-1 after 20 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of house dust mite Derp-1 after 20 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMT: 2°CAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as reduction in symmetrical dimethylation of arginine containing substrate using SmD3 as substrate i...More data for this Ligand-Target Pair