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Found 85 with Last Name = 'neelands' and Initial = 'tr'
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM20458(1-[(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-3-...)
Affinity DataKi:  7nM ΔG°:  -46.5kJ/mole EC50:  5nMpH: 7.4 T: 2°CAssay Description:The hTRPV1-expressing CHO cell membranes were incubated with [3H]A-778317 and test compounds to establish equilibrium. After incubation was terminate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM20464((2E)-3-[2-(piperidin-1-yl)-6-(trifluoromethyl)pyri...)
Affinity DataKi:  27nM ΔG°:  -43.2kJ/mole EC50:  34nMpH: 7.4 T: 2°CAssay Description:The hTRPV1-expressing CHO cell membranes were incubated with [3H]A-778317 and test compounds to establish equilibrium. After incubation was terminate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM20334(1-Isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-ur...)
Affinity DataKi:  47nM ΔG°:  -41.8kJ/mole EC50:  11nMpH: 7.4 T: 2°CAssay Description:The hTRPV1-expressing CHO cell membranes were incubated with [3H]A-778317 and test compounds to establish equilibrium. After incubation was terminate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM20465(1-[(1R,2S)-6-fluoro-1-{[3-(trifluoromethyl)phenyl]...)
Affinity DataKi:  58nM ΔG°:  -41.3kJ/mole EC50:  46nMpH: 7.4 T: 2°CAssay Description:The hTRPV1-expressing CHO cell membranes were incubated with [3H]A-778317 and test compounds to establish equilibrium. After incubation was terminate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM20285(Resiniferatoxin | [(1R,2R,6R,10S,11R,15R,17R)-13-b...)
Affinity DataKi:  65nM ΔG°:  -41.0kJ/mole EC50:  24nMpH: 7.4 T: 2°CAssay Description:The hTRPV1-expressing CHO cell membranes were incubated with [3H]A-778317 and test compounds to establish equilibrium. After incubation was terminate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM20466(A-784168 | CHEMBL482834 | N-[4-(trifluoromethane)s...)
Affinity DataKi:  71nM ΔG°:  -40.8kJ/mole EC50:  74nMpH: 7.4 T: 2°CAssay Description:The hTRPV1-expressing CHO cell membranes were incubated with [3H]A-778317 and test compounds to establish equilibrium. After incubation was terminate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM20467(3-[(1S)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-1-...)
Affinity DataKi:  112nM ΔG°:  -39.7kJ/mole EC50:  34nMpH: 7.4 T: 2°CAssay Description:The hTRPV1-expressing CHO cell membranes were incubated with [3H]A-778317 and test compounds to establish equilibrium. After incubation was terminate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM20459(Tinyatoxin | [(1R,2R,6R,10S,11R,15R,17R)-13-benzyl...)
Affinity DataKi:  589nM ΔG°:  -35.6kJ/mole EC50:  129nMpH: 7.4 T: 2°CAssay Description:The hTRPV1-expressing CHO cell membranes were incubated with [3H]A-778317 and test compounds to establish equilibrium. After incubation was terminate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM20468(3-(2-bromophenyl)-1-{2-[ethyl(3-methylphenyl)amino...)
Affinity DataKi:  603nM ΔG°:  -35.5kJ/mole EC50:  95nMpH: 7.4 T: 2°CAssay Description:The hTRPV1-expressing CHO cell membranes were incubated with [3H]A-778317 and test compounds to establish equilibrium. After incubation was terminate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM20284(CHEMBL391997 | CPZ | Capsazepine | N-[2-(4-chlorop...)
Affinity DataKi:  1.29E+3nM ΔG°:  -33.6kJ/mole EC50:  282nMpH: 7.4 T: 2°CAssay Description:The hTRPV1-expressing CHO cell membranes were incubated with [3H]A-778317 and test compounds to establish equilibrium. After incubation was terminate...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM20460((9Z)-N-[(4-hydroxy-3-methoxyphenyl)methyl]octadec-...)
Affinity DataKi:  1.59E+3nM ΔG°:  -33.1kJ/mole EC50:  132nMpH: 7.4 T: 2°CAssay Description:The hTRPV1-expressing CHO cell membranes were incubated with [3H]A-778317 and test compounds to establish equilibrium. After incubation was terminate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM20462((5Z,8Z,11Z,14Z)-N-[2-(3,4-dihydroxyphenyl)ethyl]ic...)
Affinity DataKi: >6.31E+3nM ΔG°: >-29.7kJ/mole EC50:  1.48E+3nMpH: 7.4 T: 2°CAssay Description:The hTRPV1-expressing CHO cell membranes were incubated with [3H]A-778317 and test compounds to establish equilibrium. After incubation was terminate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM20461((6E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methy...)
Affinity DataKi:  2.00E+4nM ΔG°:  -26.8kJ/mole EC50:  29nMpH: 7.4 T: 2°CAssay Description:The hTRPV1-expressing CHO cell membranes were incubated with [3H]A-778317 and test compounds to establish equilibrium. After incubation was terminate...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50056351(CHEMBL3326569)
Affinity DataIC50:  2nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50056358(CHEMBL3326581)
Affinity DataIC50:  3nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50232114((R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(...)
Affinity DataIC50:  4nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50056352(CHEMBL3326570)
Affinity DataIC50:  4nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50056434(CHEMBL3326575)
Affinity DataIC50:  4nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50056426(CHEMBL3326589)
Affinity DataIC50:  5nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50056387(CHEMBL3326582)
Affinity DataIC50:  5nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50056389(CHEMBL3326584)
Affinity DataIC50:  5nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50056408(CHEMBL3326587)
Affinity DataIC50:  5nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50056353(CHEMBL3326576)
Affinity DataIC50:  6nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50056354(CHEMBL3326577)
Affinity DataIC50:  6nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50056435(CHEMBL3326574)
Affinity DataIC50:  7nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50056436(CHEMBL3326573)
Affinity DataIC50:  7nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50056437(CHEMBL3326572)
Affinity DataIC50:  7nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50056425(CHEMBL3326588)
Affinity DataIC50:  9nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50056386(CHEMBL3325460)
Affinity DataIC50:  10nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50321851((R)-8-{5-[3-Methyl-4-(trifluoromethyl)phenyl]oxazo...)
Affinity DataIC50:  12nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50056438(CHEMBL3326571)
Affinity DataIC50:  16nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50056391(CHEMBL3326586)
Affinity DataIC50:  17nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50056439(CHEMBL3326568)
Affinity DataIC50:  21nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50056427(CHEMBL3326909)
Affinity DataIC50:  22nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50056429(CHEMBL3326914)
Affinity DataIC50:  22nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50056388(CHEMBL3326583)
Affinity DataIC50:  32nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50056390(CHEMBL3326585)
Affinity DataIC50:  32nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50056356(CHEMBL3326579)
Affinity DataIC50:  34nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50056428(CHEMBL3326915)
Affinity DataIC50:  36nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50056355(CHEMBL3326578)
Affinity DataIC50:  40nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50056431(CHEMBL3326912)
Affinity DataIC50:  60nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50056433(CHEMBL3326910)
Affinity DataIC50:  74nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50056353(CHEMBL3326576)
Affinity DataIC50:  80nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using AMMC substrate and NADPH incubated up to 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50056354(CHEMBL3326577)
Affinity DataIC50: <80nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using AMMC substrate and NADPH incubated up to 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50056351(CHEMBL3326569)
Affinity DataIC50: <80nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using AMMC substrate and NADPH incubated up to 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50056352(CHEMBL3326570)
Affinity DataIC50: <80nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using AMMC substrate and NADPH incubated up to 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50056432(CHEMBL3326911)
Affinity DataIC50:  97nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50056357(CHEMBL3326580)
Affinity DataIC50:  150nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50187697(CHEMBL3828278)
Affinity DataIC50:  160nMAssay Description:Antagonist activity at human TRPV3 expressed in recombinant HEK293 cells assessed as inhibition of 2-APB induced calcium flux by FLIPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM50056430(CHEMBL3326913)
Affinity DataIC50:  350nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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