Affinity DataKi: 0.0140nMAssay Description:The compound was evaluated for its binding affinity towards human neutrophil elastase (HNE)More data for this Ligand-Target Pair
Affinity DataKi: 0.160nM Kon: 4.90M-1s-1 Koff: 3.05E+4s-1Assay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE) using whole blood assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.160nMAssay Description:The compound was evaluated for its binding affinity towards human neutrophil elastase (HNE)More data for this Ligand-Target Pair
Affinity DataKi: 0.170nMAssay Description:Binding affinity of the compound towards Alpha1A human adrenergic receptors, using [125I]-HEAT as radioligand.More data for this Ligand-Target Pair
Affinity DataKi: 0.200nM ΔG°: -57.6kJ/mole EC50: 5.10nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Inhibition of recombinant human FLAG-tagged ITK using biotinylated GST-SAM68 as substrate after 30 minsMore data for this Ligand-Target Pair
Affinity DataKi: 0.230nMAssay Description:Binding affinity towards Alpha1A dog adrenergic receptors, using [125I]HEAT as radioligand.More data for this Ligand-Target Pair
Affinity DataKi: 0.251nMAssay Description:Inhibition of recombinant human FLAG-tagged ITK using biotinylated GST-SAM68 as substrate after 30 minsMore data for this Ligand-Target Pair
Affinity DataKi: 0.251nMAssay Description:Inhibition of recombinant human FLAG-tagged ITK using biotinylated GST-SAM68 as substrate after 30 minsMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nM ΔG°: -56.5kJ/mole EC50: 5.70nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
Affinity DataKi: 0.310nM Kon: 0.00000207M-1s-1 Koff: 6.63E+3s-1Assay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE) using whole blood assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.310nMAssay Description:The compound was evaluated for its binding affinity towards human neutrophil elastase (HNE)More data for this Ligand-Target Pair
Affinity DataKi: 0.316nMAssay Description:Inhibition of recombinant human FLAG-tagged ITK using biotinylated GST-SAM68 as substrate after 30 minsMore data for this Ligand-Target Pair
Affinity DataKi: 0.340nMAssay Description:In vitro binding affinity of the compound was determined against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]-ghrelin ...More data for this Ligand-Target Pair
Affinity DataKi: 0.360nMAssay Description:Binding affinity towards Alpha1A rat adrenergic receptors, using [125I]HEAT as radioligand.More data for this Ligand-Target Pair
Affinity DataKi: 0.398nMAssay Description:Inhibition of recombinant human FLAG-tagged ITK using biotinylated GST-SAM68 as substrate after 30 minsMore data for this Ligand-Target Pair
Affinity DataKi: 0.450nMAssay Description:In vitro binding affinity of the compound was determined against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]-ghrelin ...More data for this Ligand-Target Pair
Affinity DataKi: 0.501nMAssay Description:Inhibition of Aurora-B (unknown origin) using 5FAM-PKAtide as substrate after 120 minsMore data for this Ligand-Target Pair
Affinity DataKi: 0.590nMAssay Description:Binding affinity (low) of [3H](R)-QNB binding to Muscarinic acetylcholine receptor M1 expressed in A9 L cell line in the absence of 300 uM GTP-gamma-...More data for this Ligand-Target Pair
Affinity DataKi: 0.631nMAssay Description:Inhibition of recombinant human FLAG-tagged ITK using biotinylated GST-SAM68 as substrate after 30 minsMore data for this Ligand-Target Pair
Affinity DataKi: 0.900nMAssay Description:Displacement of [3H]DHT from human Androgen receptor in human MDA-MB-453 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.900nMAssay Description:Displacement of [3H]DHT from human Androgen receptor in human MDA-MB-453 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Inhibition of recombinant human FLAG-tagged ITK using biotinylated GST-SAM68 as substrate after 30 minsMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Antagonist activity at NK1 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Displacement of [3H]DHT from human Androgen receptor in human MDA-MB-453 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Binding affinity of [3H]-(R)-QNB binding to Muscarinic acetylcholine receptor M1 expressed in A9 L cell line in the presence of 300 uM GTP-gamma-SMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nM ΔG°: -53.0kJ/mole EC50: 6.40nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
TargetKallikrein-5(Homo sapiens (Human))
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Affinity DataKi: 1.20nMAssay Description:Inhibition of C-terminal poly-His-tagged human recombinant KLK5 (30 to 293 residues) transfected in CHO cells assessed as inhibition constant using B...More data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Displacement of [3H]DHT from human Androgen receptor in human MDA-MB-453 cellsMore data for this Ligand-Target Pair
TargetKallikrein-5(Homo sapiens (Human))
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Affinity DataKi: 1.40nMAssay Description:Inhibition of C-terminal poly-His-tagged human recombinant KLK5 (30 to 293 residues) transfected in CHO cells assessed as inhibition constant using B...More data for this Ligand-Target Pair
TargetKallikrein 1-related peptidase b5(Mus musculus)
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Affinity DataKi: 1.40nMAssay Description:Inhibition of mouse KLK5 assessed as inhibition constant using Boc-VPR-AMC as fluorogenic substrate incubated for 30 mins by fluorescence plate reade...More data for this Ligand-Target Pair
TargetKallikrein-5(Homo sapiens (Human))
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Affinity DataKi: 1.5nMAssay Description:Inhibition of C-terminal poly-His-tagged human recombinant KLK5 (30 to 293 residues) transfected in CHO cells assessed as inhibition constant using B...More data for this Ligand-Target Pair
Affinity DataKi: 1.5nM ΔG°: -52.4kJ/mole EC50: 7.10nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Inhibition of recombinant human FLAG-tagged ITK using biotinylated GST-SAM68 as substrate after 30 minsMore data for this Ligand-Target Pair
Affinity DataKi: 1.60nM ΔG°: -52.2kJ/mole EC50: 1.40nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
Affinity DataKi: 1.70nMAssay Description:The compound was evaluated for its binding affinity towards human neutrophil elastase (HNE)More data for this Ligand-Target Pair
Affinity DataKi: 1.73nM Kon: 0.0000109M-1s-1 Koff: 6.31E+3s-1Assay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE) using whole blood assayMore data for this Ligand-Target Pair
TargetKallikrein-5(Homo sapiens (Human))
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Affinity DataKi: 1.90nMAssay Description:Inhibition of C-terminal poly-His-tagged human recombinant KLK5 (30 to 293 residues) transfected in CHO cells assessed as inhibition constant using B...More data for this Ligand-Target Pair
TargetKallikrein-5(Homo sapiens (Human))
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Inhibition of C-terminal poly-His-tagged human recombinant KLK5 (30 to 293 residues) transfected in CHO cells assessed as inhibition constant using B...More data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Inhibition of recombinant human FLAG-tagged ITK using biotinylated GST-SAM68 as substrate after 30 minsMore data for this Ligand-Target Pair
TargetKallikrein-5(Homo sapiens (Human))
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Affinity DataKi: 2.20nMAssay Description:Inhibition of C-terminal poly-His-tagged human recombinant KLK5 (30 to 293 residues) transfected in CHO cells assessed as inhibition constant using B...More data for this Ligand-Target Pair
Affinity DataKi: 2.30nMAssay Description:Binding affinity (low) of [3H](R)-QNB binding to Muscarinic acetylcholine receptor M1 expressed in A9 L cell line in the absence of 300 uM GTP-gamma-...More data for this Ligand-Target Pair
Affinity DataKi: 2.40nMAssay Description:Displacement of [3H]DHT from human Androgen receptor in human MDA-MB-453 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.5nMAssay Description:Binding affinity of [3H]-(R)-QNB binding to Muscarinic acetylcholine receptor M1 expressed in A9 L cell line in the presence of 300 uM GTP-gamma-SMore data for this Ligand-Target Pair
Affinity DataKi: 2.60nMAssay Description:Displacement of [125I]NT from rat NTR1 transfected in mouse LTK cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.60nMAssay Description:Displacement of [3H]DHT from human Androgen receptor in human MDA-MB-453 cellsMore data for this Ligand-Target Pair
TargetKallikrein-5(Homo sapiens (Human))
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Affinity DataKi: 2.70nMAssay Description:Inhibition of C-terminal poly-His-tagged human recombinant KLK5 (30 to 293 residues) transfected in CHO cells assessed as inhibition constant using B...More data for this Ligand-Target Pair
TargetKallikrein-5(Homo sapiens (Human))
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Ecole Polytechnique F�D�Rale De Lausanne (Epfl)
Curated by ChEMBL
Affinity DataKi: 2.70nMAssay Description:Inhibition of C-terminal poly-His-tagged human recombinant KLK5 (30 to 293 residues) transfected in CHO cells assessed as inhibition constant using B...More data for this Ligand-Target Pair
Affinity DataKi: 2.80nM EC50: 2.70nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
Affinity DataKi: 2.80nMAssay Description:Antagonist activity at NK1 receptor (unknown origin)More data for this Ligand-Target Pair