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Found 200 with Last Name = 'prestwich' and Initial = 'gd'
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
The University Of Utah

Curated by ChEMBL
LigandPNGBDBM50350715(CHEMBL1818146)
Affinity DataKi:  6.10nMAssay Description:Inhibition of human recombinant ATX lysophospholipase activity expressed in insect sf9 cells using FS-3 fluorogenic substrate preincubated for 10 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
The University Of Utah

Curated by ChEMBL
LigandPNGBDBM50350716(CHEMBL1818147)
Affinity DataKi:  8.10nMAssay Description:Inhibition of human recombinant ATX lysophospholipase activity expressed in insect sf9 cells using FS-3 fluorogenic substrate preincubated for 10 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
The University Of Utah

Curated by ChEMBL
LigandPNGBDBM50350713(CHEMBL1818144)
Affinity DataKi:  9nMAssay Description:Inhibition of human recombinant ATX lysophospholipase activity expressed in insect sf9 cells using FS-3 fluorogenic substrate preincubated for 10 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
The University Of Utah

Curated by ChEMBL
LigandPNGBDBM50350717(CHEMBL1818148)
Affinity DataKi:  18nMAssay Description:Inhibition of human recombinant ATX lysophospholipase activity expressed in insect sf9 cells using FS-3 fluorogenic substrate preincubated for 10 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
The University Of Utah

Curated by ChEMBL
LigandPNGBDBM50350714(CHEMBL1818145)
Affinity DataKi:  24nMAssay Description:Inhibition of human recombinant ATX lysophospholipase activity expressed in insect sf9 cells using FS-3 fluorogenic substrate preincubated for 10 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
The University Of Utah

Curated by ChEMBL
LigandPNGBDBM50350721(CHEMBL1818149)
Affinity DataKi:  24nMAssay Description:Inhibition of human recombinant ATX lysophospholipase activity expressed in insect sf9 cells using FS-3 fluorogenic substrate preincubated for 10 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50018518(((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-methyl-naphtha...)
Affinity DataKi:  30nMAssay Description:Apparent inhibitory constant of the compound against squalene epoxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetLanosterol synthase(Rattus norvegicus)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50055641(2,2-dimethyl-3-((3E,7E,11E)-3,7,12-trimethyl-14-(6...)
Affinity DataKi:  37nMAssay Description:Compound was tested for kinetic inhibition constant against Oxidosqualene-lanosterol cyclase from rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysophosphatidic acid receptor 1(Homo sapiens (Human))
The University Of Utah

Curated by ChEMBL
LigandPNGBDBM50193515(1-fluoro-(3S)-hydroxyl-4-oleoyloxylbutane 1,3-cycl...)
Affinity DataKi:  60.7nMAssay Description:Activity at human LPA1 receptor expressed in RH7777 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
The University Of Utah

Curated by ChEMBL
LigandPNGBDBM50350718(CHEMBL1818150)
Affinity DataKi:  72nMAssay Description:Inhibition of human recombinant ATX lysophospholipase activity expressed in insect sf9 cells using FS-3 fluorogenic substrate preincubated for 10 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Rattus norvegicus)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50055642(2,2-Dimethyl-3-[(3E,7E,11E)-3,7,12-trimethyl-15-(4...)
Affinity DataKi:  180nMAssay Description:Compound was tested for kinetic inhibition constant against Oxidosqualene-lanosterol cyclase from rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysophosphatidic acid receptor 1(Homo sapiens (Human))
The University Of Utah

Curated by ChEMBL
LigandPNGBDBM50193518(3-hydroxyl-4-palmitoyloxylbutane 1,3-cyclic phosph...)
Affinity DataKi:  314nMAssay Description:Activity at human LPA1 receptor expressed in RH7777 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysophosphatidic acid receptor 1(Homo sapiens (Human))
The University Of Utah

Curated by ChEMBL
LigandPNGBDBM50193517(3-hydroxyl-4-oleoyloxylbutane 1,3-cyclic phosphono...)
Affinity DataKi:  403nMAssay Description:Activity at human LPA1 receptor expressed in RH7777 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Rattus norvegicus)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50055643(2,2-Dimethyl-3-[(E)-3-methyl-7-((3E,7E)-4,8,12-tri...)
Affinity DataKi:  500nMAssay Description:Compound was tested for kinetic inhibition constant against Oxidosqualene-lanosterol cyclase from pig liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
The University Of Utah

Curated by ChEMBL
LigandPNGBDBM50350719(CHEMBL1818151)
Affinity DataKi:  512nMAssay Description:Inhibition of human recombinant ATX lysophospholipase activity expressed in insect sf9 cells using FS-3 fluorogenic substrate preincubated for 10 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysophosphatidic acid receptor 3(Homo sapiens (Human))
The University Of Utah

Curated by ChEMBL
LigandPNGBDBM50193517(3-hydroxyl-4-oleoyloxylbutane 1,3-cyclic phosphono...)
Affinity DataKi:  636nMAssay Description:Activity at human LPA3 receptor expressed in RH7777 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
The University Of Utah

Curated by ChEMBL
LigandPNGBDBM50350720(CHEMBL1818153)
Affinity DataKi:  834nMAssay Description:Inhibition of human recombinant ATX lysophospholipase activity expressed in insect sf9 cells using FS-3 fluorogenic substrate preincubated for 10 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
The University Of Utah

Curated by ChEMBL
LigandPNGBDBM50350722(CHEMBL1818152)
Affinity DataKi:  1.01E+3nMAssay Description:Inhibition of human recombinant ATX lysophospholipase activity expressed in insect sf9 cells using FS-3 fluorogenic substrate preincubated for 10 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysophosphatidic acid receptor 3(Homo sapiens (Human))
The University Of Utah

Curated by ChEMBL
LigandPNGBDBM50193518(3-hydroxyl-4-palmitoyloxylbutane 1,3-cyclic phosph...)
Affinity DataKi:  1.15E+3nMAssay Description:Activity at human LPA3 receptor expressed in RH7777 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Rattus norvegicus)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50055642(2,2-Dimethyl-3-[(3E,7E,11E)-3,7,12-trimethyl-15-(4...)
Affinity DataKi:  1.40E+3nMAssay Description:Compound was tested for kinetic inhibition constant against Oxidosqualene-lanosterol cyclase from pig liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Rattus norvegicus)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50055641(2,2-dimethyl-3-((3E,7E,11E)-3,7,12-trimethyl-14-(6...)
Affinity DataKi:  1.50E+3nMAssay Description:Compound was tested for kinetic inhibition constant against Oxidosqualene-lanosterol cyclase from pig liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
The University Of Utah

Curated by ChEMBL
LigandPNGBDBM50110402(CHEMBL3605581)
Affinity DataKi:  1.79E+3nMAssay Description:Inhibition of human ATX phosphodiesterase expressed in Sf9 cells assessed as hydrolysis of FS-3 measured after 5 to 25 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50286540(1N-[20-(6-aminohexylamino)-4,8,13,17-tetramethyl-(...)
Affinity DataKi:  2.40E+3nMpH: 8.8Assay Description:The compound was tested for its inhibitory activity against pig Squalene epoxidase at pH 7.4More data for this Ligand-Target Pair
In DepthDetails Article
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
The University Of Utah

Curated by ChEMBL
LigandPNGBDBM50110424(CHEMBL3605579)
Affinity DataKi:  2.43E+3nMAssay Description:Inhibition of human ATX phosphodiesterase expressed in Sf9 cells assessed as hydrolysis of FS-3 measured after 5 to 25 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Rattus norvegicus)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50055644(2-Methyl-3-((7E,11E,15Z)-3,7,12,20-tetramethyl-16-...)
Affinity DataKi:  2.50E+3nMAssay Description:Compound was tested for kinetic inhibition constant against Oxidosqualene-lanosterol cyclase from rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Rattus norvegicus)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50290988(2,2-Dimethyl-3-(3,7,12,20-tetramethyl-16-vinyl-hen...)
Affinity DataKi:  2.50E+3nMAssay Description:Compound was evaluated for the binding affinity against rat liver oxidosqualene cyclase (OSC)More data for this Ligand-Target Pair
In DepthDetails Article
TargetLysophosphatidic acid receptor 3(Homo sapiens (Human))
The University Of Utah

Curated by ChEMBL
LigandPNGBDBM50193515(1-fluoro-(3S)-hydroxyl-4-oleoyloxylbutane 1,3-cycl...)
Affinity DataKi:  3.17E+3nMAssay Description:Activity at human LPA3 receptor expressed in RH7777 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
The University Of Utah

Curated by ChEMBL
LigandPNGBDBM50110403(CHEMBL3605580)
Affinity DataKi:  3.50E+3nMAssay Description:Inhibition of human ATX phosphodiesterase expressed in Sf9 cells assessed as hydrolysis of FS-3 measured after 5 to 25 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50279929((2Z,6E,10E,14E)-6,11,15,19-Tetramethyl-2-(4-methyl...)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibitory activity of the compound was measured against partially purified pig liver Squalene epoxidase (SE).More data for this Ligand-Target Pair
In DepthDetails Article
TargetLanosterol synthase(Rattus norvegicus)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50055644(2-Methyl-3-((7E,11E,15Z)-3,7,12,20-tetramethyl-16-...)
Affinity DataKi:  4.40E+3nMAssay Description:Compound was tested for kinetic inhibition constant against Oxidosqualene-lanosterol cyclase from pig liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Rattus norvegicus)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50055640(3-[(3E,7E)-11-((E)-4,8-Dimethyl-nona-3,7-dienylsul...)
Affinity DataKi:  4.50E+3nMAssay Description:Compound was tested for kinetic inhibition constant against Oxidosqualene-lanosterol cyclase from pig liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Rattus norvegicus)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50290991(2,2-Dimethyl-3-(3,7,12,20-tetramethyl-16-vinyl-hen...)
Affinity DataKi:  4.50E+3nMAssay Description:Compound was evaluated for the binding affinity against rat liver oxidosqualene cyclase (OSC)More data for this Ligand-Target Pair
In DepthDetails Article
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Saccharomyces cerevisiae (Baker's yeast))
The University Of Utah

Curated by ChEMBL
LigandPNGBDBM50144314((2E,4E,6E,8E)-3,7,11-trimethyldodeca-2,4,6,8,10-pe...)
Affinity DataKi:  8.80E+3nMAssay Description:Dissociation constant against yeast farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Rattus norvegicus)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50290992(3-[16-(2,2-Difluoro-vinyl)-3,7,12,20-tetramethyl-h...)
Affinity DataKi:  1.02E+4nMAssay Description:Concentration that cause 50 percent inhibition of binding of [14C]-labeled (3S)-oxidosqualene to isolated rat liver oxidosqualene cyclase (OSC) was d...More data for this Ligand-Target Pair
In DepthDetails Article
TargetLanosterol synthase(Rattus norvegicus)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50290989(3-[16-(2,2-Difluoro-vinyl)-3,7,12,20-tetramethyl-h...)
Affinity DataKi:  1.20E+4nMAssay Description:Compound was evaluated for the binding affinity against rat liver oxidosqualene cyclase (OSC)More data for this Ligand-Target Pair
In DepthDetails Article
TargetLanosterol synthase(Rattus norvegicus)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50055645((6E,10E,14E)-2,6,10,15,19-Pentamethyl-21-(3-methyl...)
Affinity DataKi:  6.00E+4nMAssay Description:Inhibition constant against rat liver Oxidosqualene-lanosterol cyclaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50018524(6,10,15,19,23-Pentamethyl-tetracosa-6,10,14,18,22-...)
Affinity DataKi:  9.50E+5nMAssay Description:Apparent inhibitory constant of the compound against squalene epoxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene monooxygenase(Homo sapiens (Human))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50018522(6,10,15,19-Tetramethyl-tetracosa-6,10,14,18-tetrae...)
Affinity DataKi:  1.00E+6nMAssay Description:Inhibitory activity against Candida albicans Squalene EpoxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50055641(2,2-dimethyl-3-((3E,7E,11E)-3,7,12-trimethyl-14-(6...)
Affinity DataIC50:  0.220nMAssay Description:Compound was tested for inhibition of purified Oxidosqualene-lanosterol cyclase from Candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50055642(2,2-Dimethyl-3-[(3E,7E,11E)-3,7,12-trimethyl-15-(4...)
Affinity DataIC50:  2.30nMAssay Description:Compound was tested for inhibition of purified Oxidosqualene-lanosterol cyclase from Candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50133285((E)-3-Carboxy-acrylateallyl-{6-[4-(4-chloro-benzoy...)
Affinity DataIC50:  4.30nMAssay Description:Tested for Oxidosqualene-lanosterol cyclase inhibition in T. bruceiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50133285((E)-3-Carboxy-acrylateallyl-{6-[4-(4-chloro-benzoy...)
Affinity DataIC50:  4.60nMAssay Description:Tested for Oxidosqualene-lanosterol cyclase inhibition in P. cariniiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50095601(CHEMBL25405 | [4-(1-Aza-bicyclo[2.2.2]oct-3-yloxy)...)
Affinity DataIC50:  22nMAssay Description:Tested for Oxidosqualene-lanosterol cyclase inhibition in T. bruceiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Rattus norvegicus)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50133285((E)-3-Carboxy-acrylateallyl-{6-[4-(4-chloro-benzoy...)
Affinity DataIC50:  49nMAssay Description:Tested for Oxidosqualene-lanosterol cyclase inhibition in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Rattus norvegicus)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50055641(2,2-dimethyl-3-((3E,7E,11E)-3,7,12-trimethyl-14-(6...)
Affinity DataIC50:  50nMAssay Description:Compound was tested for inhibition of purified Oxidosqualene-lanosterol cyclase from rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50133285((E)-3-Carboxy-acrylateallyl-{6-[4-(4-chloro-benzoy...)
Affinity DataIC50:  71nMAssay Description:Tested for Oxidosqualene-lanosterol cyclase inhibition in T. cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Homo sapiens (Human))
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50095601(CHEMBL25405 | [4-(1-Aza-bicyclo[2.2.2]oct-3-yloxy)...)
Affinity DataIC50:  92nMAssay Description:Tested for Oxidosqualene-lanosterol cyclase inhibition in P. cariniiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysophosphatidic acid receptor 1(Homo sapiens (Human))
The University Of Utah

Curated by ChEMBL
LigandPNGBDBM50193515(1-fluoro-(3S)-hydroxyl-4-oleoyloxylbutane 1,3-cycl...)
Affinity DataIC50:  106nMAssay Description:Activity at human LPA1 receptor expressed in RH7777 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Rattus norvegicus)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50055639(2-Methyl-2-(4-methyl-pent-3-enyl)-3-[(3E,7E)-3,8,1...)
Affinity DataIC50:  110nMAssay Description:Inhibition against rat liver Oxidosqualene-lanosterol cyclaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol synthase(Rattus norvegicus)
Simon Fraser University

Curated by ChEMBL
LigandPNGBDBM50095601(CHEMBL25405 | [4-(1-Aza-bicyclo[2.2.2]oct-3-yloxy)...)
Affinity DataIC50:  160nMAssay Description:Tested for Oxidosqualene-lanosterol cyclase inhibition in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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