Affinity DataKi: 0.600nMAssay Description:Inhibition of renin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Inhibition of renin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 2.20nMAssay Description:Inhibition of renin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 6nMAssay Description:Inhibition of renin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:Inhibition of renin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 19nMAssay Description:Inhibition of renin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 44nMAssay Description:Inhibition of renin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 56nMAssay Description:Inhibition of renin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 82nMAssay Description:Inhibition of renin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 86nMAssay Description:Inhibition of renin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 180nMAssay Description:Inhibition of CathD (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 420nMAssay Description:Inhibition of renin (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 480nMAssay Description:Inhibition of BACE2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 1.10E+3nMAssay Description:Inhibition of CathE (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 2.70E+3nMAssay Description:Inhibition of CathD (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 3.82E+3nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 1.95E+4nMAssay Description:Inhibition of CathD (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of renin (unknown origin)More data for this Ligand-Target Pair
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Schering-Plough Research Institute
Curated by ChEMBL
Schering-Plough Research Institute
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of gamma-secretase assessed as reduction of membrane Abeta40 levelMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of gamma-secretase mediated amyloid beta-40 production in HEK293 cell membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of renin (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of renin (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Inhibition of gamma-secretase mediated amyloid beta-40 production in HEK293 cell membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of gamma-secretase mediated amyloid beta-40 production in HEK293 cell membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Inhibition of renin (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Inhibition of gamma-secretase mediated amyloid beta-40 production in HEK293 cell membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of PS2 gamma-secretase expressed in HEK cells harboring Awe-Lon gene assessed as reduction of amyloid beta-42 productionMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cell membranes transfected with human APPSOW and APPLON mutant after 5 hrs...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of renin (unknown origin)More data for this Ligand-Target Pair
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Schering-Plough Research Institute
Curated by ChEMBL
Schering-Plough Research Institute
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Gamma-secretase activity was determined as described by Zhang et al. (Biochemistry, 40(16), 5049-5055, 2001).More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of gamma-secretase mediated amyloid beta-40 production in HEK293 cell membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cell membranes transfected with human APPSOW and APPLON mutant after 5 hrs...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of PS1 gamma-secretase assessed as reduction of amyloid beta-40 production by membrane based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cell membranes transfected with human APPSOW and APPLON mutant after 5 hrs...More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Inhibition of gamma-secretase mediated amyloid beta-40 production in HEK293 cell membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of PS2 gamma-secretase expressed in HEK cells harboring Awe-Lon gene assessed as reduction of amyloid beta-42 productionMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich imm...More data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:Inhibition of gamma-secretase mediated amyloid beta-40 production in HEK293 cell membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cell membranes transfected with human APPSOW and APPLON mutant after 5 hrs...More data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cell membranes transfected with human APPSOW and APPLON mutant after 5 hrs...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition of gamma-secretase mediated amyloid beta-40 production in HEK293 cell membranesMore data for this Ligand-Target Pair