Compile Data Set for Download or QSAR
maximum 50k data
Found 71 with Last Name = 'ratnayake' and Initial = 'r'
TargetVasopressin V2 receptor(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM35723(CHEMBL344159 | N-[4-(7-Chloro-5-hydroxy-2,3,4,5-te...)
Affinity DataIC50:  0.00700nMAssay Description:Antagonist activity at human AVPR2 by PathHunter beta-arrestin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin E(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of human recombinant cathepsin E using Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate preincubated for 15 mins f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM912((3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-m...)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of human liver cathepsin D using Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate preincubated for 15 mins followe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetHistone deacetylase 1(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50098414(CHEMBL3593247)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of recombinant full length C-terminal His/FLAG-tagged human HDAC1 expressed in baculovirus infected Sf9 insect cells using BPS HDAC substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50098414(CHEMBL3593247)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of N-terminal GST-tagged/C-terminal His-tagged human HDAC10 (1 to 481 residues) expressed in baculovirus infected Sf9 insect cells using B...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50098414(CHEMBL3593247)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of full length human C-terminal His-tagged HDAC3/N-terminal GST-tagged NCOR2 (395 to 489 residues) expressed in baculovirus infected Sf9 i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50098414(CHEMBL3593247)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of full length C-terminal FLAG-tagged human HDAC2 expressed in baculovirus infected Sf9 insect cells using BPS HDAC substrate 3 after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50242139(CHEMBL4078721)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of N-terminal GST-tagged/C-terminal His-tagged human HDAC10 (1 to 481 residues) expressed in baculovirus infected Sf9 insect cells using B...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50559938(CHEMBL154668)
Affinity DataIC50:  4.60nMAssay Description:Antagonist activity at human OXTR expressed in CHO-K1 cells by PathHunter beta-arrestin assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin E(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50400221(CHEMBL2181015)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant cathepsin E using Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate preincubated for 15 mins f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50242138(CHEMBL4099942)
Affinity DataIC50:  21nMAssay Description:Inhibition of N-terminal GST-tagged/C-terminal His-tagged human HDAC10 (1 to 481 residues) expressed in baculovirus infected Sf9 insect cells using B...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin E(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50178261(CHEMBL3813928)
Affinity DataIC50:  23nMAssay Description:Inhibition of human recombinant cathepsin E using Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate preincubated for 15 mins f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50242138(CHEMBL4099942)
Affinity DataIC50:  26nMAssay Description:Inhibition of recombinant full length C-terminal His/FLAG-tagged human HDAC1 expressed in baculovirus infected Sf9 insect cells using BPS HDAC substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50242138(CHEMBL4099942)
Affinity DataIC50:  29nMAssay Description:Inhibition of full length human C-terminal His-tagged HDAC3/N-terminal GST-tagged NCOR2 (395 to 489 residues) expressed in baculovirus infected Sf9 i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50242139(CHEMBL4078721)
Affinity DataIC50:  40nMAssay Description:Inhibition of recombinant full length C-terminal His/FLAG-tagged human HDAC1 expressed in baculovirus infected Sf9 insect cells using BPS HDAC substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50098414(CHEMBL3593247)
Affinity DataIC50:  42nMAssay Description:Inhibition of full length N-terminal GST-tagged human HDAC6 expressed in baculovirus infected Sf9 insect cells using HDAC substrate 3 after 30 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50242139(CHEMBL4078721)
Affinity DataIC50:  43nMAssay Description:Inhibition of full length human C-terminal His-tagged HDAC3/N-terminal GST-tagged NCOR2 (395 to 489 residues) expressed in baculovirus infected Sf9 i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50400221(CHEMBL2181015)
Affinity DataIC50:  50nMAssay Description:Inhibition of human liver cathepsin D using Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate preincubated for 15 mins followe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50178261(CHEMBL3813928)
Affinity DataIC50:  57nMAssay Description:Inhibition of human liver cathepsin D using Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate preincubated for 15 mins followe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50242138(CHEMBL4099942)
Affinity DataIC50:  69nMAssay Description:Inhibition of full length C-terminal FLAG-tagged human HDAC2 expressed in baculovirus infected Sf9 insect cells using BPS HDAC substrate 3 after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50400221(CHEMBL2181015)
Affinity DataIC50:  80nMAssay Description:Inhibition of BACE1 (unknown origin) using peptide substrate by time-course measurement-based fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50242139(CHEMBL4078721)
Affinity DataIC50:  90nMAssay Description:Inhibition of full length C-terminal FLAG-tagged human HDAC2 expressed in baculovirus infected Sf9 insect cells using BPS HDAC substrate 3 after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50098414(CHEMBL3593247)
Affinity DataIC50:  102nMAssay Description:Inhibition of full length C-terminal His-tagged human HDAC8 expressed in baculovirus infected Sf9 insect cells using BPS HDAC class 2a substrate afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM16034(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50:  160nMAssay Description:Inhibition of BACE1 (unknown origin) using peptide substrate by time-course measurement-based fluorescence analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50559936(CHEMBL4744046)
Affinity DataIC50:  180nMAssay Description:Antagonist activity at HTR2C in human U2OS cells by PathHunter beta-arrestin assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50559937(CHEMBL4758081)
Affinity DataIC50:  459nMAssay Description:Antagonist activity at human AVPR2 by PathHunter beta-arrestin assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50242138(CHEMBL4099942)
Affinity DataIC50:  600nMAssay Description:Inhibition of full length N-terminal GST-tagged human HDAC6 expressed in baculovirus infected Sf9 insect cells using HDAC substrate 3 after 30 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50178261(CHEMBL3813928)
Affinity DataIC50:  690nMAssay Description:Inhibition of BACE1 (unknown origin) using peptide substrate by time-course measurement-based fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM32628(FTC | Fumitremorgin C)
Affinity DataIC50:  800nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetfMet-Leu-Phe receptor(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50511108(CHEMBL4558185)
Affinity DataIC50:  1.08E+3nMAssay Description:Antagonist activity at human Gi/o-coupled FPR1 expressed in CHOK1 cells assessed as reduction in WKYMVm-NH2-induced beta-arrestin 2 recruitment incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50559937(CHEMBL4758081)
Affinity DataIC50:  1.16E+3nMAssay Description:Antagonist activity at human OXTR expressed in CHO-K1 cells by PathHunter beta-arrestin assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTranscription factor Jun(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50341205(CHEMBL1765574 | nagilactone F)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of TPA-induced AP-1 activation in cells expressing beta-lactamase after 18 hrs using FRET substrate by cell-based high-throughput screenin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50511107(CHEMBL4592258)
Affinity DataIC50:  2.26E+3nMAssay Description:Antagonist activity at human Gq-coupled HCRTR2 expressed in CHOK1 cells assessed as inhibition in Orexin A-induced beta-arrestin 2 recruitment incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProlactin-releasing peptide receptor(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50511108(CHEMBL4558185)
Affinity DataIC50:  2.43E+3nMAssay Description:Antagonist activity at human Gq-coupled PRLHR expressed in CHOK1 cells assessed as inhibition in prolactin releasing peptide (1 to 31)-induced beta-a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50242139(CHEMBL4078721)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of full length N-terminal GST-tagged human HDAC6 expressed in baculovirus infected Sf9 insect cells using HDAC substrate 3 after 30 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM19460((2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-methyl...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM50242138(CHEMBL4099942)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of full length C-terminal His-tagged human HDAC8 expressed in baculovirus infected Sf9 insect cells using BPS HDAC class 2a substrate afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide S receptor(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50511106(CHEMBL4527708)
Affinity DataIC50:  3.90E+3nMAssay Description:Antagonist activity at human Gq-coupled NPSR1b expressed in human U2OS cells assessed as inhibition in neuropeptide S-induced beta-arrestin 2 recruit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTranscription factor Jun(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50341206(CHEMBL1765575 | inumakilactone)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of TPA-induced AP-1 activation in cells expressing beta-lactamase after 18 hrs using FRET substrate by cell-based high-throughput screenin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50339152((S)-2-(3,5-dihydroxyphenyl)-5,7-dihydroxy-6,8-bis(...)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50511106(CHEMBL4527708)
Affinity DataIC50:  4.16E+3nMAssay Description:Antagonist activity at human Gq-coupled HRH1 expressed in CHOK1 cells assessed as inhibition in Orexin A-induced beta-arrestin 2 recruitment incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50511106(CHEMBL4527708)
Affinity DataIC50:  4.62E+3nMAssay Description:Antagonist activity at human GPR119 expressed in human HEK293 cells assessed as inhibition in agonist-induced beta-arrestin 2 recruitment incubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProlactin-releasing peptide receptor(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50559935(CHEMBL4780505)
Affinity DataIC50:  4.89E+3nMAssay Description:Antagonist activity at human PRLHR expressed in CHO-K1 cells by PathHunter beta-arrestin assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50511106(CHEMBL4527708)
Affinity DataIC50:  4.95E+3nMAssay Description:Antagonist activity at human Gi/o-coupled CNR1 expressed in CHOK1 cells assessed as inhibition in CP55940-induced beta-arrestin 2 recruitment incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTranscription factor Jun(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50352478(CHEMBL1823866)
Affinity DataIC50:  5.20E+3nMAssay Description:Inhibition of AP1 expressed in HEK293T cells coexpressing beta-lactamase pre-incubated 1 hr before TPA addition measured 18 hrs post TPA challenge by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50511108(CHEMBL4558185)
Affinity DataIC50:  5.20E+3nMAssay Description:Antagonist activity at human CCR8 expressed in CHOK1 cells assessed as reduction in CCL1-induced beta-arrestin 2 recruitment incubated for 30 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50064888(3',5-dihydroxy-3,4',7-trimethoxyflavone | 5-hydrox...)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50339155(6-(3,7-dimethylocta-2,6-dienyl)-3,5,7-trihydroxy-2...)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA accumulation after 2 to 20 hrs relative to fumitremorgin CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide S receptor(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50511108(CHEMBL4558185)
Affinity DataIC50:  5.77E+3nMAssay Description:Antagonist activity at human Gq-coupled NPSR1b expressed in human U2OS cells assessed as inhibition in neuropeptide S-induced beta-arrestin 2 recruit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTranscription factor Jun(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50352479(CHEMBL1823867)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of AP1 expressed in HEK293T cells coexpressing beta-lactamase pre-incubated 1 hr before TPA addition measured 18 hrs post TPA challenge by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 71 total ) | Next | Last >>
Jump to: