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Found 327 with Last Name = 'sahlberg' and Initial = 'c'
TargetCathepsin D(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50333945((S)-N-((S)-Benzylcarbamoyl-isopropylsulfanyl-methy...)
Affinity DataKi:  0.75nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50333943(CHEMBL1644461 | N1-((2S,3S,5S)-5-((S)-1-(benzylami...)
Affinity DataKi:  3.30nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50333945((S)-N-((S)-Benzylcarbamoyl-isopropylsulfanyl-methy...)
Affinity DataKi:  3.30nMAssay Description:Inhibition of reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50333945((S)-N-((S)-Benzylcarbamoyl-isopropylsulfanyl-methy...)
Affinity DataKi:  7nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50333944((S)-N-((S)-Benzylcarbamoyl-isopropylsulfanyl-methy...)
Affinity DataKi:  13nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50333943(CHEMBL1644461 | N1-((2S,3S,5S)-5-((S)-1-(benzylami...)
Affinity DataKi:  21nMAssay Description:Inhibition of reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50333946((S)-2-{(S)-2-Hydroxy-2-[(S)-18-(methanesulfonyl-me...)
Affinity DataKi:  34nMAssay Description:Inhibition of reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50333946((S)-2-{(S)-2-Hydroxy-2-[(S)-18-(methanesulfonyl-me...)
Affinity DataKi:  56nMAssay Description:Inhibition of human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50333944((S)-N-((S)-Benzylcarbamoyl-isopropylsulfanyl-methy...)
Affinity DataKi:  94nMAssay Description:Inhibition of reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50333948((S)-2-{(S)-2-Hydroxy-2-[(S)-18-(methanesulfonyl-me...)
Affinity DataKi:  130nMAssay Description:Inhibition of reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50333946((S)-2-{(S)-2-Hydroxy-2-[(S)-18-(methanesulfonyl-me...)
Affinity DataKi:  200nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50333947((S)-2-{(S)-2-Hydroxy-2-[(S)-18-(methanesulfonyl-me...)
Affinity DataKi:  340nMAssay Description:Inhibition of reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50333949((S)-2-{(S)-2-Hydroxy-2-[(S)-18-(methanesulfonyl-me...)
Affinity DataKi:  450nMAssay Description:Inhibition of reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50333949((S)-2-{(S)-2-Hydroxy-2-[(S)-18-(methanesulfonyl-me...)
Affinity DataKi:  460nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50333948((S)-2-{(S)-2-Hydroxy-2-[(S)-18-(methanesulfonyl-me...)
Affinity DataKi:  760nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50333951((S)-2-{(S)-2-Hydroxy-2-[(S)-19-(methanesulfonyl-me...)
Affinity DataKi:  940nMAssay Description:Inhibition of reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50333947((S)-2-{(S)-2-Hydroxy-2-[(S)-18-(methanesulfonyl-me...)
Affinity DataKi:  1.70E+3nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50333950((S)-2-{(S)-2-Hydroxy-2-[(S)-18-(methanesulfonyl-me...)
Affinity DataKi: >5.00E+3nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50333951((S)-2-{(S)-2-Hydroxy-2-[(S)-19-(methanesulfonyl-me...)
Affinity DataKi: >5.00E+3nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Medivir

Curated by ChEMBL
LigandPNGBDBM50333950((S)-2-{(S)-2-Hydroxy-2-[(S)-18-(methanesulfonyl-me...)
Affinity DataKi: >5.00E+3nMAssay Description:Inhibition of reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A/B(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM15581(CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)
Affinity DataIC50:  0.700nMAssay Description:In vitro Inhibitory activity of Monoamine oxidase at rat hyphalamic mitochondrial 5-HT by displacing 2.5 uM of [14C]5-HT (serotonin)More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Eli Lilly

LigandPNGBDBM2132(1-(5-bromopyridin-2-yl)-3-[2-(2-cyano-6-fluoro-3-m...)
Affinity DataIC50:  1nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Eli Lilly

LigandPNGBDBM1890(3-(5-bromopyridin-2-yl)-1-[2-(2,6-difluorophenyl)e...)
Affinity DataIC50:  1nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Eli Lilly

LigandPNGBDBM2139(1-(5-chloropyridin-2-yl)-3-[2-(2-fluoro-3,6-dimeth...)
Affinity DataIC50:  1nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Eli Lilly

LigandPNGBDBM2156(1-(5-chloropyridin-2-yl)-3-[2-(1,3-dioxo-2,3-dihyd...)
Affinity DataIC50:  1nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Eli Lilly

LigandPNGBDBM1944(BHAP deriv. | CHEMBL593 | DELAVIRDINE MESYLATE | D...)
Affinity DataIC50:  1.30nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Eli Lilly

LigandPNGBDBM2722(3-[2-(6-chloro-3-ethoxy-2-fluorophenyl)cyclopropyl...)
Affinity DataIC50:  1.30nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Medivir

Curated by ChEMBL
LigandPNGBDBM50070536(1-(5-Chloro-pyridin-2-yl)-3-[(1R,2R)-2-(3-ethoxy-2...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory effect on recombinant HIV- 1 reverse transcriptase which has a mutation Tyr 181 to Cys 181 (clone 90)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Medivir

Curated by ChEMBL
LigandPNGBDBM50070535(1-[(1R,2R)-2-(6-Chloro-3-ethoxy-2-fluoro-phenyl)-c...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory effect on wild type HIV- 1 reverse transcriptase using rCdG as template and dGTP as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Eli Lilly

LigandPNGBDBM2721(1-(5-chloropyridin-2-yl)-3-[2-(3-ethoxy-2,6-difluo...)
Affinity DataIC50:  1.60nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Medivir

Curated by ChEMBL
LigandPNGBDBM50070531(1-(5-Chloro-pyridin-2-yl)-3-[(1R,2R)-2-(2-fluoro-3...)
Affinity DataIC50:  2nMAssay Description:Compound was tested for its inhibitory effect on wild type HIV- 1 reverse transcriptase using rCdG as template and dGTP as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Medivir

Curated by ChEMBL
LigandPNGBDBM50070533(1-(5-Chloro-pyridin-2-yl)-3-[(1R,2R)-2-(2,6-difluo...)
Affinity DataIC50:  2nMAssay Description:Inhibitory effect on recombinant HIV- 1 reverse transcriptase which has a mutation Tyr 181 to Cys 181 (clone 90)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Eli Lilly

LigandPNGBDBM2159(1-(5-chloropyridin-2-yl)-3-[2-(4,7-dichloro-1,3-di...)
Affinity DataIC50:  2nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Eli Lilly

LigandPNGBDBM2143(1-(5-chloropyridin-2-yl)-3-[2-(2,4,6-trifluorophen...)
Affinity DataIC50:  2nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Eli Lilly

LigandPNGBDBM2142(1-(5-bromopyridin-2-yl)-3-[2-(6-chloro-3-ethoxy-2-...)
Affinity DataIC50:  2nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Eli Lilly

LigandPNGBDBM2131(1-(5-bromopyridin-2-yl)-3-[2-(2-cyano-3-ethoxy-6-f...)
Affinity DataIC50:  2nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Eli Lilly

LigandPNGBDBM2735((1S,2S)-N-[cis-2-(6-Fluoro-2-hydroxy-3-propionylph...)
Affinity DataIC50:  2.70nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Eli Lilly

LigandPNGBDBM2723(3-[2-(6-chloro-3-ethoxy-2-fluorophenyl)cyclopropyl...)
Affinity DataIC50:  2.70nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Eli Lilly

LigandPNGBDBM2153(3-[2-(2H-1,2,3-benzotriazol-2-yl)ethyl]-1-(5-bromo...)
Affinity DataIC50:  3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Medivir

Curated by ChEMBL
LigandPNGBDBM50070537(1-(5-Chloro-pyridin-2-yl)-3-[2-(2,6-difluoro-pheny...)
Affinity DataIC50:  3nMAssay Description:Inhibitory effect on wild type HIV- 1 reverse transcriptase using rCdG as template and dGTP as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Eli Lilly

LigandPNGBDBM2138(1-(5-bromopyridin-2-yl)-3-[2-(2,3-difluoro-6-metho...)
Affinity DataIC50:  3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Medivir

Curated by ChEMBL
LigandPNGBDBM2717(1-(5-chloropyridin-2-yl)-3-[2-(2-fluoro-3,6-dimeth...)
Affinity DataIC50:  3nMAssay Description:Inhibitory effect on wild type HIV- 1 reverse transcriptase using rCdG as template and dGTP as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Eli Lilly

LigandPNGBDBM2717(1-(5-chloropyridin-2-yl)-3-[2-(2-fluoro-3,6-dimeth...)
Affinity DataIC50:  3nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Eli Lilly

LigandPNGBDBM2133(3-[2-(2-cyano-6-fluoro-3-methoxyphenyl)ethyl]-1-(5...)
Affinity DataIC50:  3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Eli Lilly

LigandPNGBDBM2734((1R,2R)-N-[cis-2-(6-Fluoro-2-hydroxy-3-propionylph...)
Affinity DataIC50:  3.20nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Eli Lilly

LigandPNGBDBM2731(1-(5-bromopyridin-2-yl)-3-[2-(3-acetyl-6-fluoro-2-...)
Affinity DataIC50:  3.5nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Eli Lilly

LigandPNGBDBM2732((1R,2R)-N-[cis-2-(6-Fluoro-2-hydroxy-3-propionylph...)
Affinity DataIC50:  3.80nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A/B(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224952(CHEMBL441014)
Affinity DataIC50:  4nMAssay Description:In vitro inhibition of Monoamine oxidase at rat hyphalamic mitochondrial 5-HT by displacing 2.5 uM of [14C]5-HT.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Medivir

Curated by ChEMBL
LigandPNGBDBM50070530(1-[(1R,2R)-2-(2-Chloro-3-ethoxy-6-fluoro-phenyl)-c...)
Affinity DataIC50:  4nMAssay Description:Inhibitory effect on recombinant HIV- 1 reverse transcriptase which has a mutation Leu 100 to Ile 100 (clone 118)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Medivir

Curated by ChEMBL
LigandPNGBDBM2860(1-(5-bromopyridin-2-yl)-3-[2-(2-chloro-3-ethoxy-6-...)
Affinity DataIC50:  4nMAssay Description:Inhibitory effect on wild type HIV- 1 reverse transcriptase using rCdG as template and dGTP as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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