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Found 113 with Last Name = 'wrigley' and Initial = 'j'
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480056(CHEMBL468083)
Affinity DataIC50:  0.0300nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50185404((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-1-...)
Affinity DataIC50:  0.0400nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480058(CHEMBL495009)
Affinity DataIC50:  0.0600nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50185410((4aS,6S,8aR)-6-(4-chloro-benzenesulfonyl)-6-(2,5-d...)
Affinity DataIC50:  0.0600nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480052(CHEMBL467457)
Affinity DataIC50:  0.0600nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480057(CHEMBL523832)
Affinity DataIC50:  0.0600nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480051(CHEMBL512282)
Affinity DataIC50:  0.0600nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480062(CHEMBL511572)
Affinity DataIC50:  0.0700nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480065(CHEMBL495185)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50185411((4aS,6S,8aR)-6-(4-chloro-benzenesulfonyl)-6-(2,5-d...)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480059(CHEMBL523883)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480063(CHEMBL511928)
Affinity DataIC50:  0.150nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480066(CHEMBL494588)
Affinity DataIC50:  0.170nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50185407((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-3-...)
Affinity DataIC50:  0.190nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135575((S)-3-(3,4-Difluoro-phenyl)-2-methyl-N-[(S)-1-meth...)
Affinity DataIC50:  0.200nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480050(CHEMBL511375)
Affinity DataIC50:  0.210nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50185414((4aS,6S,8aR)-6-(4-chloro-benzenesulfonyl)-6-(2,5-d...)
Affinity DataIC50:  0.240nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171224(CHEMBL196215 | Cyclic sulfamide)
Affinity DataIC50:  0.240nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50185405((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-3-...)
Affinity DataIC50:  0.260nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135589((S)-3-(3,4-Difluoro-phenyl)-2-methyl-N-[(S)-1-meth...)
Affinity DataIC50:  0.300nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480054(CHEMBL506323)
Affinity DataIC50:  0.340nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50185413((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-6-...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50185408((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-6-...)
Affinity DataIC50:  0.410nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480053(CHEMBL466421)
Affinity DataIC50:  0.410nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480055(CHEMBL513674)
Affinity DataIC50:  0.420nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480060(CHEMBL466256)
Affinity DataIC50:  0.420nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480061(CHEMBL512596)
Affinity DataIC50:  0.460nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50135578(4-{3-[(S)-3-(3,4-Difluoro-phenyl)-2-methyl-propion...)
Affinity DataIC50:  0.490nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50171224(CHEMBL196215 | Cyclic sulfamide)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory concentration against gamma-secretase in whole cell SH-SY5Y assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50185406((4aS,6S,8aR)-6-(4-chloro-benzenesulfonyl)-6-(2,5-d...)
Affinity DataIC50:  0.760nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480064(CHEMBL494769)
Affinity DataIC50:  0.820nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50135579((S)-N-[(S)-5-Benzo[1,3]dioxol-5-yl-1-(2-hydroxy-et...)
Affinity DataIC50:  0.900nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50185412((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-6-...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50171213(CHEMBL194788 | Cyclic sulfamide)
Affinity DataIC50:  1nMAssay Description:Inhibitory concentration against gamma-secretase in whole cell SH-SY5Y assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50185409((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-6-...)
Affinity DataIC50:  1.17nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135584((S)-3-(3,4-Difluoro-phenyl)-2-methyl-N-[(S)-1-meth...)
Affinity DataIC50:  1.20nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50185403((+/-)-(4aS,6R,8aS)-3-tert-butyl-6-(4-chloro-benzen...)
Affinity DataIC50:  1.39nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480067(CHEMBL492394)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50135582((S)-N-((S)-5-Benzo[1,3]dioxol-5-yl-2-oxo-2,3-dihyd...)
Affinity DataIC50:  1.80nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135586((S)-N-((S)-5-Benzo[1,3]dioxol-5-yl-1-methylcarbamo...)
Affinity DataIC50:  1.80nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50171219(CHEMBL198301 | Cyclic sulfamide)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration against gamma-secretase in whole cell SH-SY5Y assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135591((S)-3-(3,4-Difluoro-phenyl)-2-methyl-N-[(S)-1-meth...)
Affinity DataIC50:  2.20nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50186575(CHEMBL377206 | cis-methyl 4-(3-(4-chlorophenylsulf...)
Affinity DataIC50:  3nMAssay Description:Inhibition of gamma secretase expressed in SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50171215(CHEMBL198302 | Cyclic sulfamide)
Affinity DataIC50:  3.40nMAssay Description:Inhibitory concentration against gamma-secretase in whole cell SH-SY5Y assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135581((S)-3-(3,4-Difluoro-phenyl)-2-methyl-N-[(S)-1-meth...)
Affinity DataIC50:  3.60nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135590((S)-N-[(S)-5-Benzo[1,3]dioxol-5-yl-2-oxo-1-(3-oxo-...)
Affinity DataIC50:  3.70nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50171223(CHEMBL195551 | Cyclic sulfamide)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration against gamma-secretase in whole cell SH-SY5Y assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135588((S)-3-(3,4-Difluoro-phenyl)-N-[(S)-5-(2,3-dihydro-...)
Affinity DataIC50:  4.70nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135577((S)-N-((S)-5-Benzo[1,3]dioxol-5-yl-1-dimethylcarba...)
Affinity DataIC50:  5.5nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50185402((+/-)-(4aS,6R,8aS)-6-(4-chloro-benzenesulfonyl)-6-...)
Affinity DataIC50:  6.18nMAssay Description:Inhibition of gamma secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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