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Found 46 with Last Name = 'zhou' and Initial = 'lm'
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50303652(1-(4-Phenoxyphenyl)piperazine | CHEMBL576512)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MSChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50303656((R)-2-[4-(4-Thiophen-3-yl-benzyl)phenoxymethyl]pyr...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MSChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50303657(3-{(R)-2-[4-(4-Chlorophenoxy)phenoxymethyl]pyrroli...)
Affinity DataIC50:  23nMAssay Description:Inhibition of human LTA4H hydrolysis assessed as inhibition of Ca2+ ionophore-stimulated LTB4 formation in human whole blood by ELISAChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50303650((R)-2-[4-(4-Chlorophenoxy)phenoxymethyl]pyrrolidin...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MSChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50294161((R)-4-(2-((4-(4-chlorophenoxy)phenoxy)methyl)pyrro...)
Affinity DataIC50:  33nMAssay Description:Inhibition of human LTA4H hydrolysis assessed as inhibition of Ca2+ ionophore-stimulated LTB4 formation in human whole blood by ELISAChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50303649(4-{(S)-2-[4-(4-Chlorophenoxy)phenoxymethyl]pyrroli...)
Affinity DataIC50:  37nMAssay Description:Inhibition of human LTA4H hydrolysis assessed as inhibition of Ca2+ ionophore-stimulated LTB4 formation in human whole blood by ELISAChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50303649(4-{(S)-2-[4-(4-Chlorophenoxy)phenoxymethyl]pyrroli...)
Affinity DataIC50:  47nMAssay Description:Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MSChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50303648((2R)-2-[(4-benzylphenoxy)methyl]pyrrolidine | (R)-...)
Affinity DataIC50:  87nMAssay Description:Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MSChecked by AuthorMore data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50303658((2S)-2-[(4-Benzylphenoxy)methyl]pyrrolidine | CHEM...)
Affinity DataIC50:  244nMAssay Description:Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MSChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50303651(1-[4-(4-Iodophenoxy)phenyl]piperazine | CHEMBL5672...)
Affinity DataIC50:  340nMAssay Description:Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MSChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50303648((2R)-2-[(4-benzylphenoxy)methyl]pyrrolidine | (R)-...)
Affinity DataIC50:  449nMAssay Description:Inhibition of human LTA4H hydrolysis assessed as inhibition of Ca2+ ionophore-stimulated LTB4 formation in human whole blood by ELISAChecked by AuthorMore data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50303650((R)-2-[4-(4-Chlorophenoxy)phenoxymethyl]pyrrolidin...)
Affinity DataIC50:  533nMAssay Description:Inhibition of human LTA4H hydrolysis assessed as inhibition of Ca2+ ionophore-stimulated LTB4 formation in human whole blood by ELISAChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Hebei University

Curated by ChEMBL
LigandPNGBDBM50391109(CHEMBL179166 | Sodium orthovanadate (SOV) | Vanada...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of recombinant human PTP1B expressed in Escherichia coli using p-nitrophenyl phosphate as substrate preincubated for 15 mins followed by s...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Hebei University

Curated by ChEMBL
LigandPNGBDBM50391109(CHEMBL179166 | Sodium orthovanadate (SOV) | Vanada...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of recombinant human TCPTP expressed in Escherichia coli using p-nitrophenyl phosphate as substrate preincubated for 15 mins followed by s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Hebei University

Curated by ChEMBL
LigandPNGBDBM50391109(CHEMBL179166 | Sodium orthovanadate (SOV) | Vanada...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of recombinant human PTP1B expressed in Escherichia coli using p-nitrophenyl phosphate as substrate preincubated for 15 mins followed by s...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Hebei University

Curated by ChEMBL
LigandPNGBDBM50391109(CHEMBL179166 | Sodium orthovanadate (SOV) | Vanada...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of recombinant human TCPTP expressed in Escherichia coli using p-nitrophenyl phosphate as substrate preincubated for 15 mins followed by s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Symphony Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50031704((2S,4R)-2-Amino-4-methyl-pentanedioic acid | (2S,4...)
Affinity DataIC50: >7.00E+3nMAssay Description:Ability of the compound to inhibit [3H]-CGS-19,755 binding to AMPA receptors.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Rattus norvegicus (Rat))
Symphony Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50031702((2R,4S)-2-Amino-4-methyl-pentanedioic acid | (4S)-...)
Affinity DataIC50: >7.00E+3nMAssay Description:Ability of the compound to inhibit [3H]-CGS-19,755 binding to Ionotropic glutamate receptor AMPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50303653(4-[2-(4-Benzylphenoxy)ethyl]pyridine | CHEMBL57813...)
Affinity DataIC50:  8.70E+3nMAssay Description:Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MSChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Rattus norvegicus (Rat))
Symphony Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50031703((2S,4S)-2-Amino-4-methyl-pentanedioic acid | 2-Ami...)
Affinity DataIC50: >1.00E+4nMAssay Description:Ability of the compound to inhibit [3H]-AMPA binding to Ionotropic glutamate receptor AMPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase S(Homo sapiens (Human))
Hebei University

Curated by ChEMBL
LigandPNGBDBM50391109(CHEMBL179166 | Sodium orthovanadate (SOV) | Vanada...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of recombinant human PTPsigma expressed in Escherichia coli using p-nitrophenyl phosphate as substrate preincubated for 15 mins followed b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase S(Homo sapiens (Human))
Hebei University

Curated by ChEMBL
LigandPNGBDBM50391109(CHEMBL179166 | Sodium orthovanadate (SOV) | Vanada...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of recombinant human PTPsigma expressed in Escherichia coli using p-nitrophenyl phosphate as substrate preincubated for 15 mins followed b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Rattus norvegicus (Rat))
Symphony Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50031705((2R,4R)-2-Amino-4-methyl-pentanedioic acid | CHEMB...)
Affinity DataIC50: >1.00E+4nMAssay Description:Ability of the compound to inhibit [3H]-CGS-19,755 binding to Ionotropic glutamate receptor AMPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Rattus norvegicus (Rat))
Symphony Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50031703((2S,4S)-2-Amino-4-methyl-pentanedioic acid | 2-Ami...)
Affinity DataIC50: >1.00E+4nMAssay Description:Ability of the compound to inhibit [3H]-CGS-19,755 binding to Ionotropic glutamate receptor AMPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Rattus norvegicus (Rat))
Symphony Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50031705((2R,4R)-2-Amino-4-methyl-pentanedioic acid | CHEMB...)
Affinity DataIC50: >1.00E+4nMAssay Description:Ability of the compound to inhibit [3H]-AMPA binding to Ionotropic glutamate receptor AMPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Hebei University

Curated by ChEMBL
LigandPNGBDBM50530497(CHEMBL4470062)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of recombinant human PTP1B expressed in Escherichia coli using p-nitrophenyl phosphate as substrate preincubated for 15 mins followed by s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Hebei University

Curated by ChEMBL
LigandPNGBDBM50530497(CHEMBL4470062)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of recombinant human PTP1B expressed in Escherichia coli using p-nitrophenyl phosphate as substrate preincubated for 15 mins followed by s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Hebei University

Curated by ChEMBL
LigandPNGBDBM50530496(CHEMBL4577930)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of recombinant human PTP1B expressed in Escherichia coli using p-nitrophenyl phosphate as substrate preincubated for 15 mins followed by s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Hebei University

Curated by ChEMBL
LigandPNGBDBM50530496(CHEMBL4577930)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of recombinant human PTP1B expressed in Escherichia coli using p-nitrophenyl phosphate as substrate preincubated for 15 mins followed by s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Hebei University

Curated by ChEMBL
LigandPNGBDBM50530495(CHEMBL4442464)
Affinity DataIC50:  2.30E+4nMAssay Description:Inhibition of recombinant human PTP1B expressed in Escherichia coli using p-nitrophenyl phosphate as substrate preincubated for 15 mins followed by s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Hebei University

Curated by ChEMBL
LigandPNGBDBM50530495(CHEMBL4442464)
Affinity DataIC50:  2.30E+4nMAssay Description:Inhibition of recombinant human PTP1B expressed in Escherichia coli using p-nitrophenyl phosphate as substrate preincubated for 15 mins followed by s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Hebei University

Curated by ChEMBL
LigandPNGBDBM50530498(CHEMBL4557312)
Affinity DataIC50:  2.70E+4nMAssay Description:Inhibition of recombinant human PTP1B expressed in Escherichia coli using p-nitrophenyl phosphate as substrate preincubated for 15 mins followed by s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Hebei University

Curated by ChEMBL
LigandPNGBDBM50530498(CHEMBL4557312)
Affinity DataIC50:  2.70E+4nMAssay Description:Inhibition of recombinant human PTP1B expressed in Escherichia coli using p-nitrophenyl phosphate as substrate preincubated for 15 mins followed by s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Hebei University

Curated by ChEMBL
LigandPNGBDBM50530495(CHEMBL4442464)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of recombinant human TCPTP expressed in Escherichia coli using p-nitrophenyl phosphate as substrate preincubated for 15 mins followed by s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Hebei University

Curated by ChEMBL
LigandPNGBDBM50530495(CHEMBL4442464)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of recombinant human TCPTP expressed in Escherichia coli using p-nitrophenyl phosphate as substrate preincubated for 15 mins followed by s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Hebei University

Curated by ChEMBL
LigandPNGBDBM50530497(CHEMBL4470062)
Affinity DataIC50:  3.70E+4nMAssay Description:Inhibition of recombinant human TCPTP expressed in Escherichia coli using p-nitrophenyl phosphate as substrate preincubated for 15 mins followed by s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Hebei University

Curated by ChEMBL
LigandPNGBDBM50530497(CHEMBL4470062)
Affinity DataIC50:  3.70E+4nMAssay Description:Inhibition of recombinant human TCPTP expressed in Escherichia coli using p-nitrophenyl phosphate as substrate preincubated for 15 mins followed by s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase S(Homo sapiens (Human))
Hebei University

Curated by ChEMBL
LigandPNGBDBM50530496(CHEMBL4577930)
Affinity DataIC50:  3.80E+4nMAssay Description:Inhibition of recombinant human PTPsigma expressed in Escherichia coli using p-nitrophenyl phosphate as substrate preincubated for 15 mins followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase S(Homo sapiens (Human))
Hebei University

Curated by ChEMBL
LigandPNGBDBM50530496(CHEMBL4577930)
Affinity DataIC50:  3.80E+4nMAssay Description:Inhibition of recombinant human PTPsigma expressed in Escherichia coli using p-nitrophenyl phosphate as substrate preincubated for 15 mins followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50294165((4-(thiophen-2-yl)phenyl)methanamine | 1-(4-thioph...)
Affinity DataIC50:  9.80E+4nMAssay Description:Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MSChecked by AuthorMore data for this Ligand-Target Pair
TargetGlutamate receptor 1(Rattus norvegicus (Rat))
Symphony Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50031702((2R,4S)-2-Amino-4-methyl-pentanedioic acid | (4S)-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Ability of the compound to inhibit [3H]-AMPA binding to Ionotropic glutamate receptor AMPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Rattus norvegicus (Rat))
Symphony Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50031704((2S,4R)-2-Amino-4-methyl-pentanedioic acid | (2S,4...)
Affinity DataIC50: >1.00E+5nMAssay Description:Ability of the compound to inhibit [3H]-AMPA binding to Ionotropic glutamate receptor AMPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50303654(CHEMBL565599 | pyridin-4-yl(4-(2-(pyrrolidin-1-yl)...)
Affinity DataIC50:  1.99E+5nMAssay Description:Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MSChecked by AuthorMore data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50303655(2-(pyridin-3-ylmethoxy)aniline | CHEMBL566838)
Affinity DataIC50: >2.00E+6nMAssay Description:Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MSChecked by AuthorMore data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50294173((4-fluorophenyl)(pyridin-4-yl)methanone | CHEMBL56...)
Affinity DataIC50:  5.38E+6nMAssay Description:Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MSChecked by AuthorMore data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50303649(4-{(S)-2-[4-(4-Chlorophenoxy)phenoxymethyl]pyrroli...)
Affinity DataKd:  25nMAssay Description:Binding affinity to human recombinant LTA4H by isothermal calorimetryChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB