Found 15 Enz. Inhib. hit(s) with Target = 'Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2'
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: 5.01E+3nMAssay Description:Inhibition of human HCN2 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of HCN2 (unknown origin) by patch clamp methodMore data for this Ligand-Target Pair
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of HCN2 (unknown origin) by patch clamp assayMore data for this Ligand-Target Pair
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human HCN2 expressed in CHO cells by automated patch clamp assayMore data for this Ligand-Target Pair
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2(Mus musculus)
Laboratory Of Design, Synthesis, And Study Of Biologically Active Heterocycles (Heterobiolab)
Curated by ChEMBL
Laboratory Of Design, Synthesis, And Study Of Biologically Active Heterocycles (Heterobiolab)
Curated by ChEMBL
Affinity DataEC50: 4.52E+3nMAssay Description:Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2(Mus musculus)
Laboratory Of Design, Synthesis, And Study Of Biologically Active Heterocycles (Heterobiolab)
Curated by ChEMBL
Laboratory Of Design, Synthesis, And Study Of Biologically Active Heterocycles (Heterobiolab)
Curated by ChEMBL
Affinity DataEC50: 5.45E+3nMAssay Description:Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2(Mus musculus)
Laboratory Of Design, Synthesis, And Study Of Biologically Active Heterocycles (Heterobiolab)
Curated by ChEMBL
Laboratory Of Design, Synthesis, And Study Of Biologically Active Heterocycles (Heterobiolab)
Curated by ChEMBL
Affinity DataEC50: 2.46E+4nMAssay Description:Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2(Mus musculus)
Laboratory Of Design, Synthesis, And Study Of Biologically Active Heterocycles (Heterobiolab)
Curated by ChEMBL
Laboratory Of Design, Synthesis, And Study Of Biologically Active Heterocycles (Heterobiolab)
Curated by ChEMBL
Affinity DataEC50: 2.30E+3nMAssay Description:Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2(Mus musculus)
Laboratory Of Design, Synthesis, And Study Of Biologically Active Heterocycles (Heterobiolab)
Curated by ChEMBL
Laboratory Of Design, Synthesis, And Study Of Biologically Active Heterocycles (Heterobiolab)
Curated by ChEMBL
Affinity DataEC50: 1.94E+4nMAssay Description:Inhibition of mouse HCN2 expressed in HEK293 cells assessed as reduction in hyperpolarization activated current at holding potential of -80 mV by pat...More data for this Ligand-Target Pair
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2(Mus musculus)
Laboratory Of Design, Synthesis, And Study Of Biologically Active Heterocycles (Heterobiolab)
Curated by ChEMBL
Laboratory Of Design, Synthesis, And Study Of Biologically Active Heterocycles (Heterobiolab)
Curated by ChEMBL
Affinity DataEC50: 15nMAssay Description:Activation of recombinant mouse HCN2 expressed in Xenopus laevis oocyte assessed as increase in current amplitude at -30 mV holding potential by patc...More data for this Ligand-Target Pair
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2(Mus musculus)
Laboratory Of Design, Synthesis, And Study Of Biologically Active Heterocycles (Heterobiolab)
Curated by ChEMBL
Laboratory Of Design, Synthesis, And Study Of Biologically Active Heterocycles (Heterobiolab)
Curated by ChEMBL
Affinity DataEC50: 1.72E+4nMAssay Description:Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2(Mus musculus)
Laboratory Of Design, Synthesis, And Study Of Biologically Active Heterocycles (Heterobiolab)
Curated by ChEMBL
Laboratory Of Design, Synthesis, And Study Of Biologically Active Heterocycles (Heterobiolab)
Curated by ChEMBL
Affinity DataEC50: 1.83E+4nMAssay Description:Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2(Mus musculus)
Laboratory Of Design, Synthesis, And Study Of Biologically Active Heterocycles (Heterobiolab)
Curated by ChEMBL
Laboratory Of Design, Synthesis, And Study Of Biologically Active Heterocycles (Heterobiolab)
Curated by ChEMBL
Affinity DataEC50: 2.55E+4nMAssay Description:Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2(Mus musculus)
Laboratory Of Design, Synthesis, And Study Of Biologically Active Heterocycles (Heterobiolab)
Curated by ChEMBL
Laboratory Of Design, Synthesis, And Study Of Biologically Active Heterocycles (Heterobiolab)
Curated by ChEMBL
Affinity DataEC50: 1.47E+5nMAssay Description:Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2(Mus musculus)
Laboratory Of Design, Synthesis, And Study Of Biologically Active Heterocycles (Heterobiolab)
Curated by ChEMBL
Laboratory Of Design, Synthesis, And Study Of Biologically Active Heterocycles (Heterobiolab)
Curated by ChEMBL
Affinity DataEC50: 5.01E+4nMAssay Description:Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair