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Found 3 Enz. Inhib. hit(s) with Target = 'ATP-dependent translocase ABCB1' and Ligand = 'BDBM50121977'
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Dr. Margarete Fischer-Bosch-Institute Of Clinical Pharmacology

Curated by ChEMBL
LigandPNGBDBM50121977(2-(3,4-Dimethoxy-phenyl)-5-[2-(3,4-dimethoxy-pheny...)
Affinity DataIC50:  300nMAssay Description:TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 5 uM) in Caco-2 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Dr. Margarete Fischer-Bosch-Institute Of Clinical Pharmacology

Curated by ChEMBL
LigandPNGBDBM50121977(2-(3,4-Dimethoxy-phenyl)-5-[2-(3,4-dimethoxy-pheny...)
Affinity DataIC50:  900nMAssay Description:TP_TRANSPORTER: inhibition of Daunorubicin efflux in NIH-3T3-G185 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Dr. Margarete Fischer-Bosch-Institute Of Clinical Pharmacology

Curated by ChEMBL
LigandPNGBDBM50121977(2-(3,4-Dimethoxy-phenyl)-5-[2-(3,4-dimethoxy-pheny...)
Affinity DataIC50:  4.24E+3nMAssay Description:Concentration required for 50% inhibition at binding site of human P-Glycoprotein (P-gp) in one-affinity modelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed