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Found 3 Enz. Inhib. hit(s) with Target = 'Beta-secretase 1' and Ligand = 'BDBM312923'
TargetBeta-secretase 1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM312923(5-But-2-ynyloxy-pyrazine-2-carboxylic acid [3-((3R...)
Affinity DataIC50:  0.200nMAssay Description:The Abeta 40 AlphaLISA Assay can be used. The HEK293 APP cells were seeded in 96 well Microtiter plates in cell culture medium (Iscove's, plus 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM312923(5-But-2-ynyloxy-pyrazine-2-carboxylic acid [3-((3R...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of BACE1 in HEK293 cells harboring APP assessed as reduction in amyloidbeta 40 level measured after 18 to 20 hrs by AlphaLISA AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM312923(5-But-2-ynyloxy-pyrazine-2-carboxylic acid [3-((3R...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human BACE1 in HEK293 cells expressing APP assessed as decrease in amyloid beta-40 level after 18 to 20 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed