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Found 3 Enz. Inhib. hit(s) with Target = 'GTPase KRas' and Ligand = 'BDBM50597323'
TargetGTPase KRas(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50597323(CHEMBL5185010)
Affinity DataIC50: <1nMAssay Description:Inhibition of recombinant biotinylated KRAS G12D mutant (unknown origin) assessed as inhibition of SOS-catalyzed nucleotide exchange preincubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGTPase KRas(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50597323(CHEMBL5185010)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of KRAS in human ASPC1 cells harboring KRAS G12D mutant assessed as inhibition of ERK phosphorylation incubated for 2 hrs by AlphaScreen-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGTPase KRas(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50597323(CHEMBL5185010)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of KRAS in human ASPC1 cells harboring KRAS G12D mutant assessed as inhibition of ERK phosphorylation incubated for 18 hrs by AlphaScreen-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed